| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis. CATALYTIC ACTIVITY: ATP + N-ribosylnicotinamide = ADP + nicotinamide ribonucleotide. CATALYTIC ACTIVITY: ATP + beta-D-ribosylnicotinate = ADP + nicotinate beta-D-ribonucleotide. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.19 mM for nicotinamide riboside (with ATP as cosubstrate); KM=30 mM for nicotinamide riboside (with GTP as cosubstrate); KM=0.11 mM for tiazofurin (with ATP as cosubstrate); KM=0.063 mM for nicotinic acid riboside (with ATP as cosubstrate); KM=1.3 mM for uridine (with ATP as cosubstrate); PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis. SUBUNIT: Monomer (By similarity). Interacts with ITGB1 alone or when associated with alpha-7, but not with alpha-5. TISSUE SPECIFICITY: Predominantly expressed in skeletal muscle and, at a much lower level, in the heart (at protein level). No expression in brain, kidney, liver, lung, pancreas nor placenta. INDUCTION: Down-regulated during myoblast differentiation (By similarity). SIMILARITY: Belongs to the uridine kinase family. NRK subfamily. SEQUENCE CAUTION: Sequence=AAF26711.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; GENE SYNONYMS:ITGB1BP3 NRK2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 230 AA; 26046 MW; 27F8275A596758E7 CRC64;
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| biopax3:xref | |
| biopax3:displayName |
NRK2_HUMAN
|
| biopax3:name |
2.7.1.173,
2.7.1.22,
ITGB1BP3,
Integrin beta-1-binding protein 3,
MIBP,
Muscle integrin-binding protein,
NRK 2,
Nicotinic acid riboside kinase 2,
NmR-K 2,
RNK 2,
Ribosylnicotinamide kinase 2,
Ribosylnicotinic acid kinase 2
|
| biopax3:organism | |
| biopax3:sequence |
MKLIVGIGGMTNGGKTTLTNSLLRALPNCCVIHQDDFFKPQDQIAVGEDGFKQWDVLESLDMEAMLDTVQAWLSSPQKFARAHGVSVQPEASDTHILLLEGFLLYSYKPLVDLYSRRYFLTVPYEECKWRRSTRNYTVPDPPGLFDGHVWPMYQKYRQEMEANGVEVVYLDGMKSREELFREVLEDIQNSLLNRSQESAPSPARPARTQGPGRGCGHRTARPAASQQDSM
|
| biopax3:standardName |
Nicotinamide riboside kinase 2
|