| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with TRAF4. Interacts (via HECT domain) with FBXL15 (via LRR repeats). Interacts with SMAD7 and TGFBR1; SMAD7 recruits SMURF1 to TGFBR1 and regulates TGF-beta receptor degradation. SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=Q9HCE7-1; Sequence=Displayed; Name=Short; IsoId=Q9HCE7-2; Sequence=VSP_006812; DOMAIN: The C2 domain mediates membrane localization and substrate selection. PTM: Ubiquitinated by the SCF(FBXL15) complex at Lys-381 and Lys- 383, leading to its degradation by the proteasome. Lys-383 is the primary ubiquitination site. SIMILARITY: Contains 1 C2 domain. SIMILARITY: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. SIMILARITY: Contains 2 WW domains. SEQUENCE CAUTION: Sequence=BAB13451.1; Type=Erroneous initiation; GENE SYNONYMS:SMURF1 KIAA1625. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 757 AA; 86114 MW; 89A171CFC47B40E9 CRC64;
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| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:16807,
urn:biopax:RelationshipXref:NCBI GENE_57154,
urn:biopax:RelationshipXref:REFSEQ_NP_001186776,
urn:biopax:RelationshipXref:REFSEQ_NP_065162,
urn:biopax:RelationshipXref:REFSEQ_NP_851994,
urn:biopax:UnificationXref:UNIPROT_A4D279,
urn:biopax:UnificationXref:UNIPROT_B7ZMB6,
urn:biopax:UnificationXref:UNIPROT_B9EGV3,
urn:biopax:UnificationXref:UNIPROT_O75853,
urn:biopax:UnificationXref:UNIPROT_Q547Q3,
urn:biopax:UnificationXref:UNIPROT_Q9HCE7,
urn:biopax:UnificationXref:UNIPROT_Q9UJT8
|
| biopax3:displayName |
SMUF1_HUMAN
|
| biopax3:name |
6.3.2.-,
SMAD ubiquitination regulatory factor 1,
SMAD-specific E3 ubiquitin-protein ligase 1,
SMURF1,
hSMURF1
|
| biopax3:organism | |
| biopax3:sequence |
MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPAPYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
|
| biopax3:standardName |
E3 ubiquitin-protein ligase SMURF1
|