| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity). SUBUNIT: Interacts with TWSG1 and/or BMP4 (By similarity). SUBCELLULAR LOCATION: Secreted (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=5; Comment=Experimental confirmation may be lacking for some isoforms; Name=1; IsoId=Q9H2X0-1; Sequence=Displayed; Name=2; IsoId=Q9H2X0-2; Sequence=VSP_001069, VSP_001070; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; Name=3; IsoId=Q9H2X0-3; Sequence=VSP_001071, VSP_001072; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; Name=4; IsoId=Q9H2X0-4; Sequence=VSP_001073, VSP_001074; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; Name=5; IsoId=Q9H2X0-5; Sequence=VSP_001075; TISSUE SPECIFICITY: Expressed at the highest level in liver. PTM: Cleaved by tolloid proteases; cleavage participates in dorsoventral patterning during early development (By similarity). SIMILARITY: Belongs to the chordin family. SIMILARITY: Contains 4 CHRD domains. SIMILARITY: Contains 4 VWFC domains. GENE SYNONYMS:CHRD. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 955 AA; 102032 MW; 53F9D9F39A517686 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:1949,
urn:biopax:RelationshipXref:NCBI GENE_8646,
urn:biopax:RelationshipXref:REFSEQ_NP_003732,
urn:biopax:UnificationXref:UNIPROT_O95254,
urn:biopax:UnificationXref:UNIPROT_Q2M1I8,
urn:biopax:UnificationXref:UNIPROT_Q6UW83,
urn:biopax:UnificationXref:UNIPROT_Q9H2D3,
urn:biopax:UnificationXref:UNIPROT_Q9H2W8,
urn:biopax:UnificationXref:UNIPROT_Q9H2W9,
urn:biopax:UnificationXref:UNIPROT_Q9H2X0,
urn:biopax:UnificationXref:UNIPROT_Q9P0Z2,
urn:biopax:UnificationXref:UNIPROT_Q9P0Z3,
urn:biopax:UnificationXref:UNIPROT_Q9P0Z4,
urn:biopax:UnificationXref:UNIPROT_Q9P0Z5
|
| biopax3:displayName |
CHRD_HUMAN
|
| biopax3:name |
CHRD
|
| biopax3:organism | |
| biopax3:sequence |
MPSLPAPPAPLLLLGLLLLGSRPARGAGPEPPVLPIRSEKEPLPVRGAAGCTFGGKVYALDETWHPDLGEPFGVMRCVLCACEAPQWGRRTRGPGRVSCKNIKPECPTPACGQPRQLPGHCCQTCPQERSSSERQPSGLSFEYPRDPEHRSYSDRGEPGAEERARGDGHTDFVALLTGPRSQAVARARVSLLRSSLRFSISYRRLDRPTRIRFSDSNGSVLFEHPAAPTQDGLVCGVWRAVPRLSLRLLRAEQLHVALVTLTHPSGEVWGPLIRHRALAAETFSAILTLEGPPQQGVGGITLLTLSDTEDSLHFLLLFRGLLEPRSGGLTQVPLRLQILHQGQLLRELQANVSAQEPGFAEVLPNLTVQEMDWLVLGELQMALEWAGRPGLRISGHIAARKSCDVLQSVLCGADALIPVQTGAAGSASLTLLGNGSLIYQVQVVGTSSEVVAMTLETKPQRRDQRTVLCHMAGLQPGGHTAVGICPGLGARGAHMLLQNELFLNVGTKDFPDGELRGHVAALPYCGHSARHDTLPVPLAGALVLPPVKSQAAGHAWLSLDTHCHLHYEVLLAGLGGSEQGTVTAHLLGPPGTPGPRRLLKGFYGSEAQGVVKDLEPELLRHLAKGMASLMITTKGSPRGELRGQVHIANQCEVGGLRLEAAGAEGVRALGAPDTASAAPPVVPGLPALAPAKPGGPGRPRDPNTCFFEGQQRPHGARWAPNYDPLCSLCTCQRRTVICDPVVCPPPSCPHPVQAPDQCCPVCPEKQDVRDLPGLPRSRDPGEGCYFDGDRSWRAAGTRWHPVVPPFGLIKCAVCTCKGGTGEVHCEKVQCPRLACAQPVRVNPTDCCKQCPVGSGAHPQLGDPMQADGPRGCRFAGQWFPESQSWHPSVPPFGEMSCITCRCGAGVPHCERDDCSLPLSCGSGKESRCCSRCTAHRRPAPETRTDPELEKEAEGS
|
| biopax3:standardName |
Chordin
|