| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. SUBUNIT: Interacts with histones. Interacts with CASK. Part of a complex containing CASK, TRB1 and TSPYL2 (By similarity). SUBCELLULAR LOCATION: Nucleus. Cytoplasm (By similarity). Note=Enriched in transcriptionally active regions of chromatin in neurons (By similarity). TISSUE SPECIFICITY: Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas. INDUCTION: Up-regulated in growth-arrested T-cells. Induced by TGFB1 and all-trans retinoic acid (ATRA) in lung cancer cells (at protein level). PTM: Phosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation (Probable). MISCELLANEOUS: Synaptic activity down-regulates TSPYL2 protein levels by inducing rapid proteasomal degradation (By similarity). MISCELLANEOUS: Subject to X inactivation. SIMILARITY: Belongs to the nucleosome assembly protein (NAP) family. SEQUENCE CAUTION: Sequence=AAG53596.1; Type=Erroneous initiation; GENE SYNONYMS:TSPYL2 CDA1 DENTT TSPX. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 693 AA; 79435 MW; 726F3BDC10A36165 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:24358,
urn:biopax:RelationshipXref:NCBI GENE_64061,
urn:biopax:RelationshipXref:REFSEQ_NP_071400,
urn:biopax:UnificationXref:UNIPROT_O94799,
urn:biopax:UnificationXref:UNIPROT_Q96DG7,
urn:biopax:UnificationXref:UNIPROT_Q9BZW6,
urn:biopax:UnificationXref:UNIPROT_Q9H2G4
|
| biopax3:displayName |
TSYL2_HUMAN
|
| biopax3:name |
CTCL-associated antigen se20-4,
Cell division autoantigen 1,
Cutaneous T-cell lymphoma-associated antigen se20-4,
Differentially-expressed nucleolar TGF-beta1 target protein,
NP79,
Nuclear protein of 79 kDa,
TSPY-like protein 2,
TSPYL2
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MDRPDEGPPAKTRRLSSSESPQRDPPPPPPPPPLLRLPLPPPQQRPRLQEETEAAQVLADMRGVGLGPALPPPPPYVILEEGGIRAYFTLGAECPGWDSTIESGYGEAPPPTESLEALPTPEASGGSLEIDFQVVQSSSFGGEGALETCSAVGWAPQRLVDPKSKEEAIIIVEDEDEDERESMRSSRRRRRRRRRKQRKVKRESRERNAERMESILQALEDIQLDLEAVNIKAGKAFLRLKRKFIQMRRPFLERRDLIIQHIPGFWVKAFLNHPRISILINRRDEDIFRYLTNLQVQDLRHISMGYKMKLYFQTNPYFTNMVIVKEFQRNRSGRLVSHSTPIRWHRGQEPQARRHGNQDASHSFFSWFSNHSLPEADRIAEIIKNDLWVNPLRYYLRERGSRIKRKKQEMKKRKTRGRCEVVIMEDAPDYYAVEDIFSEISDIDETIHDIKISDFMETTDYFETTDNEITDINENICDSENPDHNEVPNNETTDNNESADDHETTDNNESADDNNENPEDNNKNTDDNEENPNNNENTYGNNFFKGGFWGSHGNNQDSSDSDNEADEASDDEDNDGNEGDNEGSDDDGNEGDNEGSDDDDRDIEYYEKVIEDFDKDQADYEDVIEIISDESVEEEGIEEGIQQDEDIYEEGNYEEEGSEDVWEEGEDSDDSDLEDVLQVPNGWANPGKRGKTG
|
| biopax3:standardName |
Testis-specific Y-encoded-like protein 2
|