Q9H2G2

FUNCTION: Mediates apoptosis and actin stress fiber dissolution (By similarity). CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. SUBCELLULAR LOCATION: Cytoplasm (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H2G2-1; Sequence=Displayed; Name=2; IsoId=Q9H2G2-2; Sequence=VSP_018100; TISSUE SPECIFICITY: Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle. PTM: Proteolytically cleaved by caspase-3. PTM: Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. SIMILARITY: Contains 1 protein kinase domain. SIMILARITY: Contains 1 UVR domain. SEQUENCE CAUTION: Sequence=AAH47762.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 611; Sequence=AAH47885.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 422; Sequence=AAH64804.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 614; Sequence=BAA13195.2; Type=Frameshift; Positions=1172; GENE SYNONYMS:SLK KIAA0204 STK2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 1235 AA; 142695 MW; 53A43E7CA29B0ED3 CRC64;

SLK_HUMAN

urn:biopax:ModificationFeature:SLK_HUMAN_1, urn:biopax:ModificationFeature:SLK_HUMAN_10, urn:biopax:ModificationFeature:SLK_HUMAN_11, urn:biopax:ModificationFeature:SLK_HUMAN_12, urn:biopax:ModificationFeature:SLK_HUMAN_13, urn:biopax:ModificationFeature:SLK_HUMAN_14, urn:biopax:ModificationFeature:SLK_HUMAN_15, urn:biopax:ModificationFeature:SLK_HUMAN_16, urn:biopax:ModificationFeature:SLK_HUMAN_17, urn:biopax:ModificationFeature:SLK_HUMAN_18, urn:biopax:ModificationFeature:SLK_HUMAN_19, urn:biopax:ModificationFeature:SLK_HUMAN_2, urn:biopax:ModificationFeature:SLK_HUMAN_20, urn:biopax:ModificationFeature:SLK_HUMAN_21, urn:biopax:ModificationFeature:SLK_HUMAN_22, urn:biopax:ModificationFeature:SLK_HUMAN_23, urn:biopax:ModificationFeature:SLK_HUMAN_24, urn:biopax:ModificationFeature:SLK_HUMAN_25, urn:biopax:ModificationFeature:SLK_HUMAN_3, urn:biopax:ModificationFeature:SLK_HUMAN_4, urn:biopax:ModificationFeature:SLK_HUMAN_5, urn:biopax:ModificationFeature:SLK_HUMAN_6, urn:biopax:ModificationFeature:SLK_HUMAN_7, urn:biopax:ModificationFeature:SLK_HUMAN_8, urn:biopax:ModificationFeature:SLK_HUMAN_9

MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEVPIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADTDQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSGENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSTQSRISKFYPIPSLHSTGS