| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3). SUBUNIT: Interacts with EHD1, RAB4A, RAB5A, RAB14, RAB22A, RAB24 and VPS45. Binds simultaneously to RAB4A and RAB5A in vitro. Interacts with RAB4A and RAB5A that has been activated by GTP binding. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor. SIMILARITY: Contains 1 C2H2-type zinc finger. SIMILARITY: Contains 1 FYVE-type zinc finger. SIMILARITY: Contains 1 UIM (ubiquitin-interacting motif) repeat. SEQUENCE CAUTION: Sequence=BAC03860.1; Type=Erroneous initiation; Sequence=BAD92910.1; Type=Erroneous initiation; GENE SYNONYMS:ZFYVE20. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 784 AA; 88870 MW; D49E0E5A95B18616 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:20759,
urn:biopax:RelationshipXref:NCBI GENE_64145,
urn:biopax:RelationshipXref:REFSEQ_NP_071735,
urn:biopax:UnificationXref:UNIPROT_Q3KP30,
urn:biopax:UnificationXref:UNIPROT_Q59EY8,
urn:biopax:UnificationXref:UNIPROT_Q8NAQ1,
urn:biopax:UnificationXref:UNIPROT_Q9H1K0
|
| biopax3:displayName |
RBNS5_HUMAN
|
| biopax3:name |
110 kDa protein,
FYVE finger-containing Rab5 effector protein rabenosyn-5,
ZFYVE20,
Zinc finger FYVE domain-containing protein 20
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MASLDDPGEVREGFLCPLCLKDLQSFYQLHSHYEEEHSGEDRDVKGQIKSLVQKAKKAKDRLLKREGDDRAESGTQGYESFSYGGVDPYMWEPQELGAVRSHLSDFKKHRAARIDHYVVEVNKLIIRLEKLTAFDRTNTESAKIRAIEKSVVPWVNDQDVPFCPDCGNKFSIRNRRHHCRLCGSIMCKKCMELISLPLANKLTSASKESLSTHTSPSQSPNSVHGSRRGSISSMSSVSSVLDEKDDDRIRCCTHCKDTLLKREQQIDEKEHTPDIVKLYEKLRLCMEKVDQKAPEYIRMAASLNAGETTYSLEHASDLRVEVQKVYELIDALSKKILTLGLNQDPPPHPSNLRLQRMIRYSATLFVQEKLLGLMSLPTKEQFEELKKKRKEEMERKRAVERQAALESQRRLEERQSGLASRAANGEVASLRRGPAPLRKAEGWLPLSGGQGQSEDSDPLLQQIHNITSFIRQAKAAGRMDEVRTLQENLRQLQDEYDQQQTEKAIELSRRQAEEEDLQREQLQMLRERELEREREQFRVASLHTRTRSLDFREIGPFQLEPSREPRTHLAYALDLGSSPVPSSTAPKTPSLSSTQPTRVWSGPPAVGQERLPQSSMPQQHEGPSLNPFDEEDLSSPMEEATTGPPAAGVSLDPSARILKEYNPFEEEDEEEEAVAGNPFIQPDSPAPNPFSEEDEHPQQRLSSPLVPGNPFEEPTCINPFEMDSDSGPEAEEPIEEELLLQQIDNIKAYIFDAKQCGRLDEVEVLTENLRELKHTLAKQKGGTD
|
| biopax3:standardName |
Rabenosyn-5
|