| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins. SUBUNIT: Interacts with the transcriptional modulator SMAD3 and the histone deacetylase HDAC1. SUBCELLULAR LOCATION: Nucleus. Note=Excluded from nucleoli. TISSUE SPECIFICITY: Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate. PTM: The C-terminal part is phosphorylated in response to EGF signaling by the Ras/MAPK pathway. MISCELLANEOUS: TGIF2 is amplified and overexpressed in several ovarian cancer cell lines. SIMILARITY: Belongs to the TALE/TGIF homeobox family. SIMILARITY: Contains 1 homeobox DNA-binding domain. GENE SYNONYMS:TGIF2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 237 AA; 25878 MW; E78101CF7EF12555 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:15764,
urn:biopax:RelationshipXref:NCBI GENE_60436,
urn:biopax:RelationshipXref:REFSEQ_NP_001186442,
urn:biopax:RelationshipXref:REFSEQ_NP_001186443,
urn:biopax:RelationshipXref:REFSEQ_NP_001186444,
urn:biopax:RelationshipXref:REFSEQ_NP_068581,
urn:biopax:UnificationXref:UNIPROT_B2R9U3,
urn:biopax:UnificationXref:UNIPROT_E1P5T9,
urn:biopax:UnificationXref:UNIPROT_Q9GZN2
|
| biopax3:displayName |
TGIF2_HUMAN
|
| biopax3:name |
5'-TG-3'-interacting factor 2,
TGF-beta-induced transcription factor 2,
TGFB-induced factor 2,
TGIF2
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MSDSDLGEDEGLLSLAGKRKRRGNLPKESVKILRDWLYLHRYNAYPSEQEKLSLSGQTNLSVLQICNWFINARRRLLPDMLRKDGKDPNQFTISRRGGKASDVALPRGSSPSVLAVSVPAPTNVLSLSVCSMPLHSGQGEKPAAPFPRGELESPKPLVTPGSTLTLLTRAEAGSPTGGLFNTPPPTPPEQDKEDFSSFQLLVEVALQRAAEMELQKQQDPSLPLLHTPIPLVSENPQ
|
| biopax3:standardName |
Homeobox protein TGIF2
|