Q9ERU9

FUNCTION: E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1 (By similarity). CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline (omega=0). PATHWAY: Protein modification; protein sumoylation. SUBUNIT: Forms a tight complex with RANBP1 and UBE2I. Interacts with SUMO1 but not SUMO2. Interacts with sumoylated RANGAP1. Interacts with CDCA8 (By similarity). Interacts with PARK2. SUBCELLULAR LOCATION: Nucleus, nuclear pore complex (By similarity). Note=Cytoplasmic filaments (By similarity). DOMAIN: Contains F-X-F-G repeats. PTM: Polyubiquitinated by PARK2, which leads to proteasomal degradation (By similarity). SIMILARITY: Contains 1 PPIase cyclophilin-type domain. SIMILARITY: Contains 4 RanBD1 domains. SIMILARITY: Contains 6 RanBP2-type zinc fingers. SIMILARITY: Contains 3 TPR repeats. GENE SYNONYMS:Ranbp2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 3053 AA; 341121 MW; 62FD4249DEE466AE CRC64;

RBP2_MOUSE

urn:biopax:ModificationFeature:RBP2_MOUSE_1, urn:biopax:ModificationFeature:RBP2_MOUSE_10, urn:biopax:ModificationFeature:RBP2_MOUSE_11, urn:biopax:ModificationFeature:RBP2_MOUSE_12, urn:biopax:ModificationFeature:RBP2_MOUSE_13, urn:biopax:ModificationFeature:RBP2_MOUSE_14, urn:biopax:ModificationFeature:RBP2_MOUSE_15, urn:biopax:ModificationFeature:RBP2_MOUSE_16, urn:biopax:ModificationFeature:RBP2_MOUSE_17, urn:biopax:ModificationFeature:RBP2_MOUSE_18, urn:biopax:ModificationFeature:RBP2_MOUSE_19, urn:biopax:ModificationFeature:RBP2_MOUSE_2, urn:biopax:ModificationFeature:RBP2_MOUSE_20, urn:biopax:ModificationFeature:RBP2_MOUSE_21, urn:biopax:ModificationFeature:RBP2_MOUSE_22, urn:biopax:ModificationFeature:RBP2_MOUSE_23, urn:biopax:ModificationFeature:RBP2_MOUSE_24, urn:biopax:ModificationFeature:RBP2_MOUSE_25, urn:biopax:ModificationFeature:RBP2_MOUSE_26, urn:biopax:ModificationFeature:RBP2_MOUSE_27, urn:biopax:ModificationFeature:RBP2_MOUSE_28, urn:biopax:ModificationFeature:RBP2_MOUSE_29, urn:biopax:ModificationFeature:RBP2_MOUSE_3, urn:biopax:ModificationFeature:RBP2_MOUSE_30, urn:biopax:ModificationFeature:RBP2_MOUSE_31, urn:biopax:ModificationFeature:RBP2_MOUSE_32, urn:biopax:ModificationFeature:RBP2_MOUSE_33, urn:biopax:ModificationFeature:RBP2_MOUSE_34, urn:biopax:ModificationFeature:RBP2_MOUSE_35, urn:biopax:ModificationFeature:RBP2_MOUSE_36, urn:biopax:ModificationFeature:RBP2_MOUSE_37, urn:biopax:ModificationFeature:RBP2_MOUSE_38, urn:biopax:ModificationFeature:RBP2_MOUSE_39, urn:biopax:ModificationFeature:RBP2_MOUSE_4, urn:biopax:ModificationFeature:RBP2_MOUSE_40, urn:biopax:ModificationFeature:RBP2_MOUSE_41, urn:biopax:ModificationFeature:RBP2_MOUSE_42, urn:biopax:ModificationFeature:RBP2_MOUSE_43, urn:biopax:ModificationFeature:RBP2_MOUSE_44, urn:biopax:ModificationFeature:RBP2_MOUSE_45, urn:biopax:ModificationFeature:RBP2_MOUSE_5, urn:biopax:ModificationFeature:RBP2_MOUSE_6, urn:biopax:ModificationFeature:RBP2_MOUSE_7, urn:biopax:ModificationFeature:RBP2_MOUSE_8, urn:biopax:ModificationFeature:RBP2_MOUSE_9

MRRSKADVERYIASVQGSAPSPREKSMKGFYFAKLYYEAKEYDLAKKYISTYINVQERDPKAHRFLGLLYEVEENIDKAVECYKRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWVERAAKLFPGSPAIYKLKEQLLDCKGEDGWNKLFDLIQSELYARPDDIHVNIRLVELYRSNKRLKDAVAHCHEADRNTALRSSLEWNLCVVQTLKEYLESLQCLDSDKSTWRATNKDLLLAYANLMLLTLSTRDVQEGRELLESFDSALQSVKSSVGGNDELSATFLETKGHFYMHVGSLLLKMGQQSDIQWRALSELAALCYLVAFQVPRPKVKLIKGEAGQNLLETMAHDRLSQSGHMLLNLSRGKQDFLKEVVESFANKSGQSALCDALFSSQSSKERSFLGNDDIGNLDGQVPDPDDLARYDTGAVRAHNGSLQHLTWLGLQWNSLSTLPAIRKWLKQLFHHLPQETSRLETNAPESICILDLEVFLLGVIYTSHLQLKEKCNSHHTSYQPLCLPLPVCRQLCTERQKTWWDAVCTLIHRKALPGTSAKLRLLVQREINSLRGQEKHGLQPALLVHWAQSLQKTGSSLNSFYDQREYIGRSVHYWRKVLPLLKMIRKKNSIPEPIDPLFKHFHSVDIQASEIGEYEEDAHITFAILDAVNGNIEDAMTAFESIKNVVSYWNLALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIRILDDSDSNTSVVQKLPVPLESVKEMLNSVMQELEDYSEGGTLYKNGCWRSADSELKHSTPSPTKYSLSPSKSYKYSPKTPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSNNSASPHRWPAEPYGQDPAPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKGPVYGMNRLPPQQHIYAYSQQMHTPPVQSSSACMFSQEMYGPPLRFESPATGILSPRGDDYFNYNVQQTSTNPPLPEPGYFTKPPLVAHASRSAESKVIEFGKSNFVQPMQGEVIRPPLTTPAHTTQPTPFKFNSNFKSNDGDFTFSSPQVVAQPPSTAYSNSESLLGLLTSDKPLQGDGYSGLKPISGQASGSRNTFSFGSKNTLTENMGPNQQKNFGFHRSDDMFAFHGPGKSVFTTAASELANKSHETDGGSAHGDEEDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAKLFRFDGESKEWKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGSDRSFVWHALDYADELPKPEQLAIRFKTPEEAALFKCKFEEAQNILKALGTNTSTAPNHTLRIVKESATQDNKDICKADGGNLNFEFQIVKKEGPYWNCNSCSFKNAATAKKCVSCQNTNPTSNKELLGPPLVENGFAPKTGLENAQDRFATMTANKEGHWDCSVCLVRNEPTVSRCIACQNTKSASSFVQTSFKFGQGDLPKSVDSDFRSVFSKKEGQWECSVCLVRNERSAKKCVACENPGKQFKEWHCSLCSVKNEAHAIKCVACNNPVTPSLSTAPPSFKFGTSEMSKPFRIGFEGMFAKKEGQWDCSLCFVRNEASATHCIACQYPNKQNQPTSCVSAPASSETSRSPKSGFEGLFPKKEGEWECAVCSVQNESSSLKCVACEASKPTHKPHEAPSAFTVGSKSQSNESAGSQVGTEFKSNFPEKNFKVGISEQKFKFGHVDQEKTPSFAFQGGSNTEFKSIKDGFSFCIPVSADGFKFGIQEKGNQEKKSEKHLENDPSFQAHDTSGQKNGSGVVFGQTSSTFTFADLAKSTSREGFQFGKKDPNFKGFSGAGEKLFSSQSGKVAEKANTSSDLEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRVKLFRFDAEISQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSGSDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDTGRAAKLIQRAEEMKSGLKDFKTFLTNDQVKVTDEENASSGADAPSASDTTAKQNPDNTGPALEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKSPAKLNQSGASVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLYRYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQTMKGTERVWVWTACDFADGERKIEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSHLSTPRESPCGKIAIAVLEETTRERTDLTQGDEVIDTTSEAGETSSTSETTPKAVVSPPKFVFGSESVKSIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKNSNSEMTSRVQSGSEGKVKPDKCELPQNSDIKQSSDGKVKNLSAFSKENSSTSYTFKTPEKAQEKSKPEDLPSDNDILIVYELTPTPEQKALAEKLLLPSTFFCYKNRPGYVSEEEEDDEDYEMAVKKLNGKLYLDDSEKPLEENLADNDKECVIVWEKKPTVEERAKADTLKLPPTFFCGVCSDTDEDNGNGEDFQSELRKVCEAQKSQNEKVTDRVGIEHIGETEVTNPVGCKSEEPDSDTKHSSSSPVSGTMDKPVDLSTRKETDMEFPSKGENKPVLFGFGSGTGLSFADLASSNSGDFAFGSKDKNFQWANTGAAVFGTQTTSKGGEDEDGSDEDVVHNEDIHFEPIVSLPEVEVKSGEEDEEVLFKERAKLYRWDRDVSQWKERGIGDIKILWHTMKKYYRILMRRDQVFKVCANHVITKAMELKPLNVSNNALVWTASDYADGEAKVEQLAVRFKTKEMTESFKKKFEECQQNIIKLQNGHTSLAAELSKDTNPVVFFDVCADGEPLGRIIMELFSNIVPQTAENFRALCTGEKGFGFKNSIFHRVVPDFICQGGDITKYNGTGGQSIYGDKFDDENFDLKHTGPGLLSMANYGQNTNSSQFFITLKKAEHLDFKHVVFGFVKDGMDTVRKIESFGSPKGSVSRRICITECGQL