| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: May mediate the intracellular trafficking of ceramide in a non-vesicular manner (By similarity). SUBUNIT: Interacts with VAPA and VAPB. Interaction with VAPB is less efficient than with VAPA (By similarity). Interacts with COL4A3. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Golgi apparatus (By similarity). Endoplasmic reticulum (By similarity). Note=Preferentially localized to the Golgi apparatus (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9EQG9-1; Sequence=Displayed; Name=2; Synonyms=Delta26, GPBPD26; IsoId=Q9EQG9-2; Sequence=VSP_006277; Name=3; IsoId=Q9EQG9-3; Sequence=VSP_028735, VSP_028736; Note=No experimental confirmation available; DOMAIN: The START domain recognizes ceramide and mediates the intermembrane transfer of ceramide (By similarity). DOMAIN: The PH domain targets the Golgi apparatus (By similarity). DOMAIN: The FFAT motif is required for interaction with VAPA and VAPB (By similarity). PTM: Phosphorylation on Ser-132 decreases the affinity toward phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity. Inactivated by hyperphosphorylation of serine residues by CSNK1G2/CK1 that triggers dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis (By similarity). SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 START domain. SEQUENCE CAUTION: Sequence=AAH16197.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part; GENE SYNONYMS:Col4a3bp Stard11. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 624 AA; 71111 MW; FD708AFFB25FCD31 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:MOUSE GENOME DATABASE_MGI:1915268,
urn:biopax:RelationshipXref:NCBI GENE_68018,
urn:biopax:RelationshipXref:REFSEQ_NP_001157694,
urn:biopax:RelationshipXref:REFSEQ_NP_075909,
urn:biopax:UnificationXref:UNIPROT_Q3TQF6,
urn:biopax:UnificationXref:UNIPROT_Q8BNN8,
urn:biopax:UnificationXref:UNIPROT_Q8C8H3,
urn:biopax:UnificationXref:UNIPROT_Q8CAR3,
urn:biopax:UnificationXref:UNIPROT_Q91WB1,
urn:biopax:UnificationXref:UNIPROT_Q9CU52,
urn:biopax:UnificationXref:UNIPROT_Q9EQG8,
urn:biopax:UnificationXref:UNIPROT_Q9EQG9
|
| biopax3:displayName |
C43BP_MOUSE
|
| biopax3:name |
Ceramide transfer protein,
Col4a3bp,
GPBP,
Goodpasture antigen-binding protein,
START domain-containing protein 11,
StAR-related lipid transfer protein 11,
StARD11
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNTLSYYKSEDETEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPEHRQQWVDAIEQHKTESGYGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQKYFDVCADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHNTNGNKEKLFPHVTPKGINGIDFKGEAITFKATTAGILATLSHCIELMVKREESWQKRHDREVEKRRRVEEAYKNVMEELKKKPRFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDTFSSVGTHRFVQKPYSRSSSMSSIDLVSASDDVHRFSSQVEEMVQNHMNYSLQDVGGDANWQLVVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHVVETLADNAIIVYQTHKRVWPASQRDVLYLSAIRKIPALTENDPETWIVCNFSVDHDSAPLNNRCVRAKINIAMICQTLVSPPEGDQEISRDNILCKITYVANVNPGGWAPASVLRAVAKREYPKFLKRFTSYVQEKTAGKPILF
|
| biopax3:standardName |
Collagen type IV alpha-3-binding protein
|