| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta- cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3- 25-hydroxylase activity (By similarity). CATALYTIC ACTIVITY: 5-beta-cholestane-3-alpha,7-alpha,12-alpha- triol + NADPH + O(2) = (25R)-5-beta-cholestane-3-alpha,7-alpha,12- alpha,26-tetraol + NADP(+) + H(2)O. COFACTOR: Heme group (By similarity). PATHWAY: Hormone biosynthesis; cholecalciferol biosynthesis. SUBCELLULAR LOCATION: Mitochondrion membrane (By similarity). PTM: Acetylation of Lys-125 and Lys-285 is observed in liver mitochondria from fasted mice but not from fed mice. SIMILARITY: Belongs to the cytochrome P450 family. GENE SYNONYMS:Cyp27a1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 533 AA; 60720 MW; A7F808CA505EF4E6 CRC64;
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| biopax3:xref | |
| biopax3:displayName |
CP27A_MOUSE
|
| biopax3:name |
1.14.13.15,
5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase,
Cyp27a1,
Cytochrome P-450C27/25,
Cytochrome P450 27,
Sterol 27-hydroxylase,
Vitamin D(3) 25-hydroxylase
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| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MAAWSRTRLRWTLLDPRVVGRGLCPQGARAKATIPAALQAQESTEGPGTGQDRPRLRSPAELPGTGTLQFLFQLFLQGYVLHLPDLQVLNKTKYGPMWTTSFGTYTNVNLASAPLLEQVMRQEGKYPIRDHMDQWKDHRDHKGLTYGIFIAQGEQWYHLRQALKQRLLKPDEAALYTDALNEVISDFITRLDQVRAESESGDQVPDMAHLLYHLALEAITYILFEKRIGCLKPSIPEDTAAFIRSVAIMFQNSVYITFLPKWTRPLLPFWKRYLNGWDNIFSFGKKLIDEKVQELKAQLQETGPDGVRVSGYLHFLLTNELLSTQETIGTFPELLLAGVDTTSNTLTWALYHLSKSPEIQEALHKEVTGVVPFGKVPQHKDFAHMPLLKAVIKETLRLYPVVPTNSRIITEKETEINGFLFPKNTQFVLCHYVVSRDPSVFPEPNSFQPHRWLRKKEADNPGILHPFGSVPFGYGVRSCLGRRIAELEMQLMLSRLVQKYEIALAPGMGEVKTVSRIVLVPSKKVRLHFLQRQ
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| biopax3:standardName |
Sterol 26-hydroxylase, mitochondrial
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