| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron (By similarity). SUBUNIT: Identified in the spliceosome C complex. Heterodimer with U2AF2. Interacts with ZRANB2 (By similarity). Interacts (via RS domain) with PHF5A (via N-terminus). SUBCELLULAR LOCATION: Nucleus. Nucleus speckle. TISSUE SPECIFICITY: Expressed in primary spermatocytes and elongating spermatids (at protein level). DOMAIN: The C-terminal SR-rich domain is required for interactions with SR proteins and the splicing regulators TRA and TRA2, and the N-terminal domain is required for formation of the U2AF1/U2AF2 heterodimer (By similarity). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). SIMILARITY: Belongs to the splicing factor SR family. SIMILARITY: Contains 2 C3H1-type zinc fingers. SIMILARITY: Contains 1 RRM (RNA recognition motif) domain. GENE SYNONYMS:U2af1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 239 AA; 27815 MW; DFF944210581244D CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:MOUSE GENOME DATABASE_MGI:98884,
urn:biopax:RelationshipXref:NCBI GENE_108121,
urn:biopax:RelationshipXref:REFSEQ_NP_001157241,
urn:biopax:RelationshipXref:REFSEQ_NP_077149,
urn:biopax:UnificationXref:UNIPROT_Q564E4,
urn:biopax:UnificationXref:UNIPROT_Q99LX2,
urn:biopax:UnificationXref:UNIPROT_Q9CZ98,
urn:biopax:UnificationXref:UNIPROT_Q9D883
|
| biopax3:displayName |
U2AF1_MOUSE
|
| biopax3:name |
U2 auxiliary factor 35 kDa subunit,
U2 snRNP auxiliary factor small subunit,
U2af1
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQTIALLNIYRNPQNSSQSADGLRCAVSDVEMQEHYDEFFEEVFTEMEEKYGEVEEMNVCDNLGDHLVGNVYVKFRREEDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEMGECTRGGFCNFMHLKPISRELRRELYGRRRKKHRSRSRSRERRSRSRDRGRGGGGGGGGGGGRERDRRRSRDRERSGRF
|
| biopax3:standardName |
Splicing factor U2AF 35 kDa subunit
|