Q9C0K0

FUNCTION: Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). SUBUNIT: Interacts with TFCOUP1, SIRT1, ARP1 and EAR2 (By similarity). SUBCELLULAR LOCATION: Nucleus (Potential). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Alpha; IsoId=Q9C0K0-1; Sequence=Displayed; Name=2; IsoId=Q9C0K0-2; Sequence=VSP_009565; Note=May be due to exon skipping; TISSUE SPECIFICITY: Highly expressed in brain and in malignant T- cell lines derived from patients with adult T-cell leukemia/lymphoma. SIMILARITY: Contains 6 C2H2-type zinc fingers. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/BCL11BID392.html"; GENE SYNONYMS:BCL11B CTIP2 RIT1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 894 AA; 95519 MW; DF6C467AE2EEC122 CRC64;

BC11B_HUMAN

urn:biopax:ModificationFeature:BC11B_HUMAN_1, urn:biopax:ModificationFeature:BC11B_HUMAN_10, urn:biopax:ModificationFeature:BC11B_HUMAN_11, urn:biopax:ModificationFeature:BC11B_HUMAN_12, urn:biopax:ModificationFeature:BC11B_HUMAN_13, urn:biopax:ModificationFeature:BC11B_HUMAN_14, urn:biopax:ModificationFeature:BC11B_HUMAN_15, urn:biopax:ModificationFeature:BC11B_HUMAN_16, urn:biopax:ModificationFeature:BC11B_HUMAN_17, urn:biopax:ModificationFeature:BC11B_HUMAN_18, urn:biopax:ModificationFeature:BC11B_HUMAN_19, urn:biopax:ModificationFeature:BC11B_HUMAN_2, urn:biopax:ModificationFeature:BC11B_HUMAN_20, urn:biopax:ModificationFeature:BC11B_HUMAN_21, urn:biopax:ModificationFeature:BC11B_HUMAN_3, urn:biopax:ModificationFeature:BC11B_HUMAN_4, urn:biopax:ModificationFeature:BC11B_HUMAN_5, urn:biopax:ModificationFeature:BC11B_HUMAN_6, urn:biopax:ModificationFeature:BC11B_HUMAN_7, urn:biopax:ModificationFeature:BC11B_HUMAN_8, urn:biopax:ModificationFeature:BC11B_HUMAN_9

MSRRKQGNPQHLSQRELITPEADHVEAAILEEDEGLEIEEPSGLGLMVGGPDPDLLTCGQCQMNFPLGDILVFIEHKRKQCGGSLGACYDKALDKDSPPPSSRSELRKVSEPVEIGIQVTPDEDDHLLSPTKGICPKQENIAGPCRPAQLPAVAPIAASSHPHSSVITSPLRALGALPPCLPLPCCSARPVSGDGTQGEGQTEAPFGCQCQLSGKDEPSSYICTTCKQPFNSAWFLLQHAQNTHGFRIYLEPGPASSSLTPRLTIPPPLGPEAVAQSPLMNFLGDSNPFNLLRMTGPILRDHPGFGEGRLPGTPPLFSPPPRHHLDPHRLSAEEMGLVAQHPSAFDRVMRLNPMAIDSPAMDFSRRLRELAGNSSTPPPVSPGRGNPMHRLLNPFQPSPKSPFLSTPPLPPMPPGGTPPPQPPAKSKSCEFCGKTFKFQSNLIVHRRSHTGEKPYKCQLCDHACSQASKLKRHMKTHMHKAGSLAGRSDDGLSAASSPEPGTSELAGEGLKAADGDFRHHESDPSLGHEPEEEDEEEEEEEEELLLENESRPESSFSMDSELSRNRENGGGGVPGVPGAGGGAAKALADEKALVLGKVMENVGLGALPQYGELLADKQKRGAFLKRAAGGGDAGDDDDAGGCGDAGAGGAVNGRGGGFAPGTEPFPGLFPRKPAPLPSPGLNSAAKRIKVEKDLELPPAALIPSENVYSQWLVGYAASRHFMKDPFLGFTDARQSPFATSSEHSSENGSLRFSTPPGDLLDGGLSGRSGTASGGSTPHLGGPGPGRPSSKEGRRSDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTHGQIGKEVYRCDICQMPFSVYSTLEKHMKKWHGEHLLTNDVKIEQAERS