| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Regulates myosin phosphatase activity. SUBUNIT: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12C mediates binding to myosin. Interacts via its N-terminus with PPP1CB. Interacts with IL16. Interacts with the coiled-coil domain of MPRIP. SUBCELLULAR LOCATION: Cytoplasm. Note=Along actomyosin filaments and stress fibers. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9BZL4-1; Sequence=Displayed; Name=2; IsoId=Q9BZL4-2; Sequence=VSP_052643; Note=No experimental confirmation available; Name=3; IsoId=Q9BZL4-3; Sequence=VSP_030750, VSP_030751; Note=No experimental confirmation available; Name=4; IsoId=Q9BZL4-4; Sequence=VSP_030751; Note=No experimental confirmation available; TISSUE SPECIFICITY: Ubiquitously expressed. Highly expressed in heart. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylation at Thr-560 is essential for its interaction with PPP1CB. SIMILARITY: Contains 4 ANK repeats. CAUTION: Although assigned as two separate genes (PPP1R12C and LENG3), it is probable that LENG3 does not exist by itself and is a part of the PPP1R12C gene. SEQUENCE CAUTION: Sequence=AF211968; Type=Miscellaneous discrepancy; Note=Unspliced mRNA; Sequence=BAB15651.1; Type=Erroneous initiation; Sequence=BAC85179.1; Type=Erroneous initiation; GENE SYNONYMS:PPP1R12C LENG3 MBS85. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 782 AA; 84881 MW; 677E7EB1B62C2CC8 CRC64;
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| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:14947,
urn:biopax:RelationshipXref:NCBI GENE_54776,
urn:biopax:RelationshipXref:REFSEQ_NP_060077,
urn:biopax:UnificationXref:UNIPROT_Q59FK8,
urn:biopax:UnificationXref:UNIPROT_Q6ZPD1,
urn:biopax:UnificationXref:UNIPROT_Q7L8F7,
urn:biopax:UnificationXref:UNIPROT_Q96HW1,
urn:biopax:UnificationXref:UNIPROT_Q9BZL4,
urn:biopax:UnificationXref:UNIPROT_Q9H5H5,
urn:biopax:UnificationXref:UNIPROT_Q9NT00
|
| biopax3:displayName |
PP12C_HUMAN
|
| biopax3:name |
PPP1R12C,
Protein phosphatase 1 myosin-binding subunit of 85 kDa,
Protein phosphatase 1 myosin-binding subunit p85
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MSGEDGPAAGPGAAAAAARERRREQLRQWGARAGAEPGPGERRARTVRFERAAEFLAACAGGDLDEARLMLRAADPGPGAELDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLADEEVLSLLEELARKQEDLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKERRPGGAGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSSPPHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPEPSVLSEVTKPPPCLENSSPPSRIPEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKAAGKAPESEKPAQSLDPSRRPRVPGVENSDSPAQRAEAPDGQGPGPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSARRQRWQRDLNPEPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAERPALLELERFERRALERKAAELEEELKALSDLRADNQRLKDENAALIRVISKLSK
|
| biopax3:standardName |
Protein phosphatase 1 regulatory subunit 12C
|