| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. SUBUNIT: Forms homodimers and homotrimers. Binds to the fibrillized forms of beta amyloid peptide 40 (beta-APP40) and beta amyloid peptide 42 (beta-APP42). Found associated with beta-APP42 more frequently than with beta-APP40. SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (Potential). Note=After proteolytic cleavage, CLAC is secreted. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9BXS0-1; Sequence=Displayed; Name=2; IsoId=Q9BXS0-2; Sequence=VSP_052200; Name=3; IsoId=Q9BXS0-3; Sequence=VSP_052197, VSP_052198, VSP_052199; TISSUE SPECIFICITY: Expressed predominantly in brain. Deposited preferentially in primitive or neuritic amyloid plaques which are typical of Alzheimer disease. PTM: Undergoes proteolytic cleavage by furin protease to yield the soluble collagen-like Alzheimer amyloid plaque component. PTM: Glycosylated. PTM: Hydroxylated on 11% of proline residues and 49% of lysine residues. SIMILARITY: Contains 7 collagen-like domains. CAUTION: The pyrrolidone carboxylic acid reported in PubMed:11927537 probably formed artifactually from Glu-113 during the extraction procedure in 70% formic acid. In PubMed:15522881, the protein was found to have unblocked Glu at the N-terminus. GENE SYNONYMS:COL25A1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 654 AA; 64771 MW; D6DFB4FB157C05A2 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:18603,
urn:biopax:RelationshipXref:NCBI GENE_84570,
urn:biopax:RelationshipXref:REFSEQ_NP_115907,
urn:biopax:RelationshipXref:REFSEQ_NP_942014,
urn:biopax:UnificationXref:UNIPROT_A8MPZ6,
urn:biopax:UnificationXref:UNIPROT_Q9BXR9,
urn:biopax:UnificationXref:UNIPROT_Q9BXS0
|
| biopax3:displayName |
COPA1_HUMAN
|
| biopax3:name |
AMY,
Alzheimer disease amyloid-associated protein,
CLAC,
CLAC-P,
COL25A1,
Collagen-like Alzheimer amyloid plaque component
|
| biopax3:organism | |
| biopax3:sequence |
MLLKKHAGKGGGREPRSEDPTPAEQHCARTMPPCAVLAALLSVVAVVSCLYLGVKTNDLQARIAALESAKGAPSIHLLPDTLDHLKTMVQEKVERLLAQKSYEHMAKIRIAREAPSECNCPAGPPGKRGKRGRRGESGPPGQPGPQGPPGPKGDKGEQGDQGPRMVFPKINHGFLSADQQLIKRRLIKGDQGQAGPPGPPGPPGPRGPPGDTGKDGPRGMPGVPGEPGKPGEQGLMGPLGPPGQKGSIGAPGIPGMNGQKGEPGLPGAVGQNGIPGPKGEPGEQGEKGDAGENGPKGDTGEKGDPGSSAAGIKGEPGESGRPGQKGEPGLPGLPGLPGIKGEPGFIGPQGEPGLPGLPGTKGERGEAGPPGRGERGEPGAPGPKGKQGESGTRGPKGSKGDRGEKGDSGAQGPRGPPGQKGDQGATEIIDYNGNLHEALQRITTLTVTGPPGPPGPQGLQGPKGEQGSPGIPGMDGEQGLKGSKGDMGDPGMTGEKGGIGLPGLPGANGMKGEKGDSGMPGPQGPSIIGPPGPPGPHGPPGPMGPHGLPGPKGTDGPMGPHGPAGPKGERGEKGAMGEPGPRGPYGLPGKDGEPGLDGFPGPRGEKGDLGEKGEKGFRGVKGEKGEPGQPGLDGLDAPCQLGPDGLPMPGCWQK
|
| biopax3:standardName |
Collagen alpha-1(XXV) chain
|