| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA with chain length from C6 to C16 in an NADPH-dependent manner with preference to medium chain length substrate. May have a role in the mitochondrial synthesis of fatty acids. CATALYTIC ACTIVITY: Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=37 uM for trans-2-hexenoyl-CoA; KM=7.1 uM for trans-2-decenoyl-CoA; SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Mitochondrion. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BV79-1; Sequence=Displayed; Name=2; IsoId=Q9BV79-2; Sequence=VSP_041131; Note=No experimental confirmation available; TISSUE SPECIFICITY: Highly expressed in skeletal and heart muscle. Expressed at lower level in placenta, liver, kidney and pancreas. Weakly or not expressed in lung. SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. SEQUENCE CAUTION: Sequence=AAD34058.1; Type=Frameshift; Positions=14, 19; GENE SYNONYMS:MECR NBRF1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 373 AA; 40462 MW; DB13F6B0ED54A823 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:19691,
urn:biopax:RelationshipXref:NCBI GENE_51102,
urn:biopax:RelationshipXref:REFSEQ_NP_001019903,
urn:biopax:RelationshipXref:REFSEQ_NP_057095,
urn:biopax:UnificationXref:UNIPROT_B3KT72,
urn:biopax:UnificationXref:UNIPROT_Q5SYU0,
urn:biopax:UnificationXref:UNIPROT_Q5SYU1,
urn:biopax:UnificationXref:UNIPROT_Q5SYU2,
urn:biopax:UnificationXref:UNIPROT_Q6IBU9,
urn:biopax:UnificationXref:UNIPROT_Q9BV79,
urn:biopax:UnificationXref:UNIPROT_Q9Y373
|
| biopax3:displayName |
MECR_HUMAN
|
| biopax3:name |
1.3.1.38,
HsNrbf-1,
MECR,
NRBF-1,
Nuclear receptor-binding factor 1
|
| biopax3:organism | |
| biopax3:sequence |
MWVCSTLWRVRTPARQWRGLLPASGCHGPAASSYSASAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQILTM
|
| biopax3:standardName |
Trans-2-enoyl-CoA reductase, mitochondrial
|