| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions. SUBUNIT: Interacts with MPP5, PARD6A and INADL. SUBCELLULAR LOCATION: Apical cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=A; IsoId=Q9BUF7-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q9BUF7-2; Sequence=VSP_013989; TISSUE SPECIFICITY: Preferentially expressed in epithelial tissues. Expressed at high levels in lung, kidney, retina, colon and mammary glands. Expressed at moderate levels in liver, spleen, pancreas, placenta and prostate. DOMAIN: The PDZ-binding motif is involved in the interactions with PARD6A and MPP5. GENE SYNONYMS:CRB3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 120 AA; 12854 MW; F0CCDE3D91E7392D CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:20237,
urn:biopax:RelationshipXref:NCBI GENE_92359,
urn:biopax:RelationshipXref:REFSEQ_NP_631900,
urn:biopax:RelationshipXref:REFSEQ_NP_777377,
urn:biopax:UnificationXref:UNIPROT_A8KA91,
urn:biopax:UnificationXref:UNIPROT_D6W643,
urn:biopax:UnificationXref:UNIPROT_Q8N0V8,
urn:biopax:UnificationXref:UNIPROT_Q8WVA0,
urn:biopax:UnificationXref:UNIPROT_Q9BUF7
|
| biopax3:displayName |
CRUM3_HUMAN
|
| biopax3:name |
CRB3
|
| biopax3:organism | |
| biopax3:sequence |
MANPGLGLLLALGLPFLLARWGRAWGQIQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVGLALLVRKLREKRQTEGTYRPSSEEQVGARVPPTPNLKLPPEERLI
|
| biopax3:standardName |
Crumbs protein homolog 3
|