| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity). Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase. SUBUNIT: Interacts with MAP3K1, SMAD4 and TRAF6. Interacts with SMAD1 only after BMP4-treatment (By similarity). Interacts with NDUFAF1. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Mitochondrion. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BQ95-1; Sequence=Displayed; Name=2; IsoId=Q9BQ95-2; Sequence=VSP_026345, VSP_026346; SIMILARITY: Belongs to the ECSIT family. GENE SYNONYMS:ECSIT. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 431 AA; 49148 MW; 42AFEBFFA6953C80 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:29548,
urn:biopax:RelationshipXref:NCBI GENE_51295,
urn:biopax:RelationshipXref:REFSEQ_NP_001135936,
urn:biopax:RelationshipXref:REFSEQ_NP_057665,
urn:biopax:UnificationXref:UNIPROT_Q96HQ7,
urn:biopax:UnificationXref:UNIPROT_Q9BQ95,
urn:biopax:UnificationXref:UNIPROT_Q9NYI1
|
| biopax3:displayName |
ECSIT_HUMAN
|
| biopax3:name |
ECSIT,
Protein SITPEC
|
| biopax3:organism | |
| biopax3:sequence |
MSWVQATLLARGLCRAWGGTCGAALTGTSISQVPRRLPRGLHCSAAAHSSEQSLVPSPPEPRQRPTKALVPFEDLFGQAPGGERDKASFLQTVQKFAEHSVRKRGHIDFIYLALRKMREYGVERDLAVYNQLLNIFPKEVFRPRNIIQRIFVHYPRQQECGIAVLEQMENHGVMPNKETEFLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVPRDLPQDPVELAMFGLRHMEPDLSARVTIYQVPLPKDSTGAADPPQPHIVGIQSPDQQAALARHNPARPVFVEGPFSLWLRNKCVYYHILRADLLPPEEREVEETPEEWNLYYPMQLDLEYVRSGWDNYEFDINEVEEGPVFAMCMAGAHDQATMAKWIQGLQETNPTLAQIPVVFRLAGSTRELQTSSAGLEEPPLPEDHQEEDDNLQRQQQGQS
|
| biopax3:standardName |
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
|