| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. SUBUNIT: Monomer; in cytoplasm. Homodimer; when associated with membranes (By similarity). Interacts with OPHN1 (By similarity). Interacts with SYNJ1 and DNM1. Interacts with MAP4K3; the interaction appears to regulate MAP4K3-mediated JNK activation. Interacts with PDCD6IP. Interacts with ATX2. SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Note=Concentrated in presynaptic nerve terminals in neurons. TISSUE SPECIFICITY: Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum. DOMAIN: An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. The BAR domain dimer forms a rigid crescent shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface. MISCELLANEOUS: HeLa cells expressing the N-BAR domain of SH3GL2 show tubulation of the plasma membrane. The N-BAR domain binds liposomes and induces formation of tubules from liposomes. The N- terminal amphipathic helix is required for liposome binding. The second amphipathic helix enhances liposome tubulation. SIMILARITY: Belongs to the endophilin family. SIMILARITY: Contains 1 BAR domain. SIMILARITY: Contains 1 SH3 domain. GENE SYNONYMS:SH3GL2 CNSA2 SH3D2A. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 352 AA; 39962 MW; F3AE2353E1EB7CF3 CRC64;
|
| biopax3:xref | |
| biopax3:displayName |
SH3G2_HUMAN
|
| biopax3:name |
EEN-B1,
Endophilin-1,
SH3 domain protein 2A,
SH3 domain-containing GRB2-like protein 2,
SH3GL2
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKPSGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVALPH
|
| biopax3:standardName |
Endophilin-A1
|