| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD). SUBUNIT: May form trimers with the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit and SMURF1. Interacts with SUV39H1 and SUV39H2. Interacts (via MH2 domain) with LEMD3. Interacts with WWP1. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. TISSUE SPECIFICITY: Ubiquitous. PTM: Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase. PTM: Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1. SIMILARITY: Belongs to the dwarfin/SMAD family. SIMILARITY: Contains 1 MH1 (MAD homology 1) domain. SIMILARITY: Contains 1 MH2 (MAD homology 2) domain. GENE SYNONYMS:SMAD5 MADH5. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 465 AA; 52258 MW; 4A1FD7EC7BD06728 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:6771,
urn:biopax:RelationshipXref:NCBI GENE_4090,
urn:biopax:RelationshipXref:REFSEQ_NP_001001419,
urn:biopax:RelationshipXref:REFSEQ_NP_001001420,
urn:biopax:RelationshipXref:REFSEQ_NP_005894,
urn:biopax:UnificationXref:UNIPROT_O14688,
urn:biopax:UnificationXref:UNIPROT_Q15798,
urn:biopax:UnificationXref:UNIPROT_Q99717,
urn:biopax:UnificationXref:UNIPROT_Q9UQA1
|
| biopax3:displayName |
SMAD5_HUMAN
|
| biopax3:name |
JV5-1,
MAD homolog 5,
Mothers against DPP homolog 5,
SMAD 5,
SMAD family member 5,
SMAD5,
Smad5,
hSmad5
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQPNNTPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDNSQPMDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS
|
| biopax3:standardName |
Mothers against decapentaplegic homolog 5
|