| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. ENZYME REGULATION: GAP activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and, to a lesser extent, by phosphatidylinositol 3,4,5-trisphosphate (PIP3). Phosphatidic acid potentiates PIP2 stimulation. SUBUNIT: Isoform 1 interacts with EPB41L1, PLCG1, NF2, HOMER1 and HOMER2 (By similarity). Isoform 2 interacts with activated AKT1 in the presence of guanine nucleotides, and with the AP-1 complex. SUBCELLULAR LOCATION: Isoform 1: Cytoplasm. Nucleus. SUBCELLULAR LOCATION: Isoform 2: Cytoplasm. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=PIKE-L; IsoId=Q99490-1; Sequence=Displayed; Name=2; Synonyms=PIKE-A; IsoId=Q99490-2; Sequence=VSP_018531, VSP_018532, VSP_018533; Note=Phosphorylated by FYN; TISSUE SPECIFICITY: Isoform 1 is brain-specific. Isoform 2 is ubiquitously expressed, with highest levels in brain and heart. DOMAIN: G domain binds GTP and has GTPase activity. DOMAIN: Arf-GAP domain interacts with G domain and may regulate its GTPase activity. DOMAIN: Although both PH domains of isoforms 1 and 2 bind phospholipids, they differently regulate subcellular location. PH domain of isoform 1 directs the protein to the nucleus, but PH domain of isoform 2 directs it to the cytosol. PH domain of isoform 2 is required for binding to AP-1. PTM: Isoform PIKE-A is phosphorylated at Tyr-682 and Tyr-774 by FYN, preventing its apoptotic cleavage. SIMILARITY: Belongs to the centaurin gamma-like family. SIMILARITY: Contains 2 ANK repeats. SIMILARITY: Contains 1 Arf-GAP domain. SIMILARITY: Contains 1 PH domain. SEQUENCE CAUTION: Sequence=BAA11484.2; Type=Erroneous initiation; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CENTG1ID44037ch12q14.html"; GENE SYNONYMS:AGAP2 CENTG1 KIAA0167. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 1192 AA; 124674 MW; 8DA53707C0127984 CRC64;
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| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:16921,
urn:biopax:RelationshipXref:NCBI GENE_116986,
urn:biopax:RelationshipXref:REFSEQ_NP_001116244,
urn:biopax:RelationshipXref:REFSEQ_NP_055585,
urn:biopax:UnificationXref:UNIPROT_A8K9F7,
urn:biopax:UnificationXref:UNIPROT_O00578,
urn:biopax:UnificationXref:UNIPROT_Q548E0,
urn:biopax:UnificationXref:UNIPROT_Q8IWU3,
urn:biopax:UnificationXref:UNIPROT_Q99490
|
| biopax3:displayName |
AGAP2_HUMAN
|
| biopax3:name |
AGAP-2,
AGAP2,
Centaurin-gamma-1,
Cnt-g1,
GGAP2,
GTP-binding and GTPase-activating protein 2,
PIKE,
Phosphatidylinositol 3-kinase enhancer
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:AGAP2_HUMAN_1,
urn:biopax:ModificationFeature:AGAP2_HUMAN_2,
urn:biopax:ModificationFeature:AGAP2_HUMAN_3,
urn:biopax:ModificationFeature:AGAP2_HUMAN_4,
urn:biopax:ModificationFeature:AGAP2_HUMAN_5,
urn:biopax:ModificationFeature:AGAP2_HUMAN_6,
urn:biopax:ModificationFeature:AGAP2_HUMAN_7
|
| biopax3:organism | |
| biopax3:sequence |
MSRGAGALQRRTTTYLISLTLVKLESVPPPPPSPSAAAVGAPGARGSEPRDPGSPRGAEEPGKKRHERLFHRQDALWISTSSAGAGGAEPPALSPAPASPARPVSPAPGRRLSLWAAPPGPPLSGGLSPDSKPGGAPSSSRRPLLSSPSWGGPEPEGRTGGGVPGSSSPHPGTGSRRLKVAPPPPAPKPCKTVTTSGAKAGGGKGAGSRLSWPESEGKPRVKGSKSSAGTGASVSAAATAAAAGGGGSTASTSGGVGAGAGARGKLSPRKGKSKTLDNSDLHPGPPAGSPPPLTLPPTPSPATAVTAASAQPPGPAPPITLEPPAPGLKRGREGGRASTRDRKMLKFISGIFTKSTGGPPGSGPLPGPPSLSSGSGSRELLGAELRASPKAVINSQEWTLSRSIPELRLGVLGDARSGKSSLIHRFLTGSYQVLEKTESEQYKKEMLVDGQTHLVLIREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGLALALVGTQDRISASSPRVVGDARARALCADMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRKQQQLLAACKSLPSSPSHSAASTPVAGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSDSEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGPSASINGLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPSGDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGEGGSAATTPSAATTPSITATPSPRRRSSAASVGRADAPVALV
|
| biopax3:standardName |
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
|