| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking. SUBUNIT: Interacts with BMX. May interact with SSB. Interacts with RAB4 and RAB5 that have been activated by GTP-binding. SUBCELLULAR LOCATION: Cytoplasm. Early endosome membrane; Peripheral membrane protein. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=rabip4'; IsoId=Q96T51-1; Sequence=Displayed; Name=2; Synonyms=rabip4; IsoId=Q96T51-2; Sequence=VSP_019785; Name=3; IsoId=Q96T51-3; Sequence=VSP_019786, VSP_019787; Note=No experimental confirmation available; TISSUE SPECIFICITY: Broadly expressed, with highest levels in lung, testis, kidney and brain. DOMAIN: The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is substantially increased in acidic conditions. PTM: Phosphorylation on Tyr-389 and/or Tyr-400 is required for interaction with BMX and endosomal targeting. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 1 FYVE-type zinc finger. SIMILARITY: Contains 1 RUN domain. SEQUENCE CAUTION: Sequence=AAK50771.1; Type=Frameshift; Positions=47, 88; Sequence=BAB15276.1; Type=Erroneous initiation; GENE SYNONYMS:RUFY1 RABIP4 ZFYVE12. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 708 AA; 79818 MW; 6697B4BC108AD54F CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:19760,
urn:biopax:RelationshipXref:NCBI GENE_80230,
urn:biopax:RelationshipXref:REFSEQ_NP_001035541,
urn:biopax:RelationshipXref:REFSEQ_NP_001035542,
urn:biopax:RelationshipXref:REFSEQ_NP_079434,
urn:biopax:UnificationXref:UNIPROT_Q59FF3,
urn:biopax:UnificationXref:UNIPROT_Q71S93,
urn:biopax:UnificationXref:UNIPROT_Q96T51,
urn:biopax:UnificationXref:UNIPROT_Q9H6I3
|
| biopax3:displayName |
RUFY1_HUMAN
|
| biopax3:name |
FYVE-finger protein EIP1,
La-binding protein 1,
RUFY1,
Rab4-interacting protein,
Zinc finger FYVE domain-containing protein 12
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MADREGGCAAGRGRELEPELEPGPGPGSALEPGEEFEIVDRSQLPGPGDLRSATRPRAAEGWSAPILTLARRATGNLSASCGSALRAAAGLGGGDSGDGTARAASKCQMMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIGQNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKDVQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSTAS
|
| biopax3:standardName |
RUN and FYVE domain-containing protein 1
|