| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. ENZYME REGULATION: Activity is inhibited by 4,4'-Di- isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters), gluconate, and by thiosulfate. SUBUNIT: Interacts with RACGAP1. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Note=Located at the annulus ring structure within the sperm cell. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q96RN1-1; Sequence=Displayed; Name=2; IsoId=Q96RN1-2; Sequence=VSP_052705; Note=No experimental confirmation available; Name=3; IsoId=Q96RN1-3; Sequence=VSP_052704, VSP_052706; Note=No experimental confirmation available; Name=4; IsoId=Q96RN1-4; Sequence=VSP_052707, VSP_052708; Note=No experimental confirmation available; TISSUE SPECIFICITY: Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell. Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the spermatocytes and spermatids. Expressed in spermatozoa. INDUCTION: Repressed by tunicamycin, an inhibitor of N- glycosylation. PTM: N-glycosylated. SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. SIMILARITY: Contains 1 STAS domain. SEQUENCE CAUTION: Sequence=AAO26699.1; Type=Miscellaneous discrepancy; Note=Incorrectly indicated as originating from mouse; Sequence=BAB71408.1; Type=Erroneous initiation; GENE SYNONYMS:SLC26A8 TAT1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 970 AA; 109006 MW; 7F932A9CFE3A9EC4 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:14468,
urn:biopax:RelationshipXref:NCBI GENE_116369,
urn:biopax:RelationshipXref:REFSEQ_NP_001180405,
urn:biopax:RelationshipXref:REFSEQ_NP_443193,
urn:biopax:RelationshipXref:REFSEQ_NP_619732,
urn:biopax:UnificationXref:UNIPROT_Q5JVR5,
urn:biopax:UnificationXref:UNIPROT_Q812C7,
urn:biopax:UnificationXref:UNIPROT_Q8TC65,
urn:biopax:UnificationXref:UNIPROT_Q96MA0,
urn:biopax:UnificationXref:UNIPROT_Q96PK8,
urn:biopax:UnificationXref:UNIPROT_Q96RN1
|
| biopax3:displayName |
S26A8_HUMAN
|
| biopax3:name |
Anion exchange transporter,
SLC26A8,
Solute carrier family 26 member 8
|
| biopax3:organism | |
| biopax3:sequence |
MAQLERSAISGFSSKSRRNSFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHVQCRCSWHRFLRCVLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSFVKNEFSAPSYLMGYNKSLSVVATTTFLTGIIQLIMGVLGLGFIATYLPESAMSAYLAAVALHIMLSQLTFIFGIMISFHAGPISFFYDIINYCVALPKANSTSILVFLTVVVALRINKCIRISFNQYPIEFPMELFLIIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKEVDMVKVPLKEEEIFSLFNSSDTNLQGGKICRCFCNCDDLEPLPRILYTERFENKLDPEASSINLIHCSHFESMNTSQTASEDQVPYTVSSVSQKNQGQQYEEVEEVWLPNNSSRNSSPGLPDVAESQGRRSLIPYSDASLLPSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGITKTQLFLSVHDAVLFALSRKVIGSSELSIDESETVIRETYSETDKNDNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDLDRELEPEMEPKAETETKTQTEMEPQPETEPEMEPNPKSRPRAHTFPQQRYWPMYHPSMASTQSQTQTRTWSVERRRHPMDSYSPEGNSNEDV
|
| biopax3:standardName |
Testis anion transporter 1
|