| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus. SUBUNIT: Heterodimer of NR1H4 and RXR. After activation by agonist binding, interacts with a coactivator, NCOA1 or NCOA2 (By similarity). Interacts with CARM1 and SMARD1. SUBCELLULAR LOCATION: Nucleus (Probable). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q96RI1-3; Sequence=Displayed; Name=2; IsoId=Q96RI1-4; Sequence=VSP_003665; Name=3; IsoId=Q96RI1-1; Sequence=VSP_010135; Name=4; IsoId=Q96RI1-2; Sequence=VSP_010135, VSP_003665; SIMILARITY: Belongs to the nuclear hormone receptor family. NR1 subfamily. SIMILARITY: Contains 1 nuclear receptor DNA-binding domain. WEB RESOURCE: Name=Wikipedia; Note=Farnesoid X receptor entry; URL="http://en.wikipedia.org/wiki/Farnesoid_X_receptor"; GENE SYNONYMS:NR1H4 BAR FXR HRR1 RIP14. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 486 AA; 55914 MW; C23283576A8CF76B CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:7967,
urn:biopax:RelationshipXref:NCBI GENE_9971,
urn:biopax:RelationshipXref:REFSEQ_NP_001193906,
urn:biopax:RelationshipXref:REFSEQ_NP_001193907,
urn:biopax:RelationshipXref:REFSEQ_NP_001193908,
urn:biopax:RelationshipXref:REFSEQ_NP_001193921,
urn:biopax:RelationshipXref:REFSEQ_NP_001193922,
urn:biopax:RelationshipXref:REFSEQ_NP_005114,
urn:biopax:UnificationXref:UNIPROT_A1L4K5,
urn:biopax:UnificationXref:UNIPROT_B7Z412,
urn:biopax:UnificationXref:UNIPROT_B7ZM06,
urn:biopax:UnificationXref:UNIPROT_Q8NFP5,
urn:biopax:UnificationXref:UNIPROT_Q8NFP6,
urn:biopax:UnificationXref:UNIPROT_Q92943,
urn:biopax:UnificationXref:UNIPROT_Q96RI1
|
| biopax3:displayName |
NR1H4_HUMAN
|
| biopax3:name |
Farnesoid X-activated receptor,
Farnesol receptor HRR-1,
NR1H4,
Nuclear receptor subfamily 1 group H member 4,
RXR-interacting protein 14,
Retinoid X receptor-interacting protein 14
|
| biopax3:organism | |
| biopax3:sequence |
MVMQFQGLENPIQISPHCSCTPSGFFMEMMSMKPAKGVLTEQVAGPLGQNLEVEPYSQYSNVQFPQVQPQISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTKKPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ
|
| biopax3:standardName |
Bile acid receptor
|