| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity). SUBUNIT: Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1CC. Interacts with PPP1CA, WDR82 and TOX4 (By similarity). SUBCELLULAR LOCATION: Nucleus. Note=Found in discrete nucleoplasmic bodies and within nucleoli. Associates with chromatin during interphase, excluded from condensed chromosomes during early mitosis and is reloaded onto chromosomes at the late telophase (By similarity). TISSUE SPECIFICITY: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. PTM: Phosphorylated on Ser-398 and Thr-400 by PKA within the region necessary for interaction with PPP1CA (By similarity). SIMILARITY: Contains 1 C3H1-type zinc finger. SIMILARITY: Contains 1 TFIIS N-terminal domain. GENE SYNONYMS:PPP1R10 CAT53 FB19 PNUTS. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 940 AA; 99058 MW; 49EE42961D734121 CRC64;
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| biopax3:xref | |
| biopax3:displayName |
PP1RA_HUMAN
|
| biopax3:name |
MHC class I region proline-rich protein CAT53,
PP1-binding protein of 114 kDa,
PPP1R10,
Phosphatase 1 nuclear targeting subunit,
Protein FB19,
p99
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:PP1RA_HUMAN_1,
urn:biopax:ModificationFeature:PP1RA_HUMAN_2,
urn:biopax:ModificationFeature:PP1RA_HUMAN_3,
urn:biopax:ModificationFeature:PP1RA_HUMAN_4,
urn:biopax:ModificationFeature:PP1RA_HUMAN_5,
urn:biopax:ModificationFeature:PP1RA_HUMAN_6,
urn:biopax:ModificationFeature:PP1RA_HUMAN_7,
urn:biopax:ModificationFeature:PP1RA_HUMAN_8
|
| biopax3:organism | |
| biopax3:sequence |
MGSGPIDPKELLKGLDSFLNRDGEVKSVDGISKIFSLMKEARKMVSRCTYLNILLQTRSPEILVKFIDVGGYKLLNNWLTYSKTTNNIPLLQQILLTLQHLPLTVDHLKQNNTAKLVKQLSKSSEDEELRKLASVLVSDWMAVIRSQSSTQPAEKDKKKRKDEGKSRTTLPERPLTEVKAETRAEEAPEKKREKPKSLRTTAPSHAKFRSTGLELETPSLVPVKKNASTVVVSDKYNLKPIPLKRQSNVAAPGDATPPAEKKYKPLNTTPNATKEIKVKIIPPQPMEGLGFLDALNSAPVPGIKIKKKKKVLSPTAAKPSPFEGKTSTEPSTAKPSSPEPAPPSEAMDADRPGTPVPPVEVPELMDTASLEPGALDAKPVESPGDPNQLTRKGRKRKSVTWPEEGKLREYFYFELDETERVNVNKIKDFGEAAKREILSDRHAFETARRLSHDNMEEKVPWVCPRPLVLPSPLVTPGSNSQERYIQAEREKGILQELFLNKESPHEPDPEPYEPIPPKLIPLDEECSMDETPYVETLEPGGSGGSPDGAGGSKLPPVLANLMGSMGAGKGPQGPGGGGINVQEILTSIMGSPNSHPSEELLKQPDYSDKIKQMLVPHGLLGPGPIANGFPPGGPGGPKGMQHFPPGPGGPMPGPHGGPGGPVGPRLLGPPPPPRGGDPFWDGPGDPMRGGPMRGGPGPGPGPYHRGRGGRGGNEPPPPPPPFRGARGGRSGGGPPNGRGGPGGGMVGGGGHRPHEGPGGGMGNSSGHRPHEGPGGGMGSGHRPHEGPGGSMGGGGGHRPHEGPGGGISGGSGHRPHEGPGGGMGAGGGHRPHEGPGGSMGGSGGHRPHEGPGHGGPHGHRPHDVPGHRGHDHRGPPPHEHRGHDGPGHGGGGHRGHDGGHSHGGDMSNRPVCRHFMMKGNCRYENNCAFYHPGVNGPPLP
|
| biopax3:standardName |
Serine/threonine-protein phosphatase 1 regulatory subunit 10
|