| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Inhibits the interaction of APBA2 with beta-amyloid precursor protein (APP), and hence allows formation of beta- amyloid. SUBUNIT: Interacts with the N-terminal domain of APBA2. Interacts with NEK2. SUBCELLULAR LOCATION: Golgi apparatus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms; Name=2; Synonyms=XB51-alpha; IsoId=Q96P71-1; Sequence=Displayed; Name=1; Synonyms=XB51-beta; IsoId=Q96P71-2; Sequence=VSP_000739; Name=3; IsoId=Q96P71-3; Sequence=VSP_000737, VSP_000738; Note=May result from the retention of an intron in the cDNA; TISSUE SPECIFICITY: Strongly expressed in heart and skeletal muscle, moderately in brain and pancreas. PTM: Phosphorylated by NEK2. SIMILARITY: Contains 1 ABM domain. SIMILARITY: Contains 1 EF-hand domain. SEQUENCE CAUTION: Sequence=BAB14649.1; Type=Frameshift; Positions=56; Sequence=BAB16413.1; Type=Erroneous initiation; GENE SYNONYMS:NECAB3 APBA2BP NIP1 SYTIP2 XB51. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 396 AA; 44350 MW; 9B24503AA629CB45 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:15851,
urn:biopax:RelationshipXref:NCBI GENE_63941,
urn:biopax:RelationshipXref:REFSEQ_NP_112508,
urn:biopax:RelationshipXref:REFSEQ_NP_112509,
urn:biopax:UnificationXref:UNIPROT_A8K780,
urn:biopax:UnificationXref:UNIPROT_E1P5N2,
urn:biopax:UnificationXref:UNIPROT_Q5JWF5,
urn:biopax:UnificationXref:UNIPROT_Q5JWF6,
urn:biopax:UnificationXref:UNIPROT_Q5JWF7,
urn:biopax:UnificationXref:UNIPROT_Q86VV1,
urn:biopax:UnificationXref:UNIPROT_Q96P71,
urn:biopax:UnificationXref:UNIPROT_Q9H433,
urn:biopax:UnificationXref:UNIPROT_Q9H8G8,
urn:biopax:UnificationXref:UNIPROT_Q9HBW7,
urn:biopax:UnificationXref:UNIPROT_Q9HCQ9
|
| biopax3:displayName |
NECA3_HUMAN
|
| biopax3:name |
Amyloid beta A4 protein-binding family A member 2-binding protein,
NECAB3,
Nek2-interacting protein 1,
Neuronal calcium-binding protein 3,
X11L-binding protein 51
|
| biopax3:organism | |
| biopax3:sequence |
MACAGLLTVCLLRPPAPQPQPQTPRHPQLAPDPGPAGHTLFQDVFRRADKNDDGKLSFEEFQNYFADGVLSLGELQELFSGIDGHLTDNLETEKLCDYFSEHLGVYRPVLAALESLNRAVLAAMDATKLEYERASKVDQFVTRFLLRETVSQLQALQSSLEGASDTLEAQAHGWRSDAESVEAQSRLCGSRRAGRRALRSVSRSSTWSPGSSDTGRSSEAEMQWRLQVNRLQELIDQLECKVRAVGPGPHKGGPSWYPPEPGPCWRPGPHSVPSQAPRLEPLREEDLAKGPDLHILMAQRQVQVAEEGLQDFHRALRCYVDFTGAQSHCLHVSAQKMLDGASFTLYEFWQDEASWRRHQQSPGSKAFQRILIDHLRAPDTLTTVFFPASWWIMNNN
|
| biopax3:standardName |
N-terminal EF-hand calcium-binding protein 3
|