| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity. SUBUNIT: Binds to NOP2, DAXX, PINX1, TERT and Herpes simplex virus ICP22. Interacts with CCDC85B. Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Note=In microspherules in the nucleolus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q96EZ8-1; Sequence=Displayed; Name=2; Synonyms=MCRS2; IsoId=Q96EZ8-2; Sequence=VSP_016260; Name=3; IsoId=Q96EZ8-3; Sequence=VSP_016259; Note=No experimental confirmation available. May be due to intron retention; TISSUE SPECIFICITY: Detected in testis, and at lower levels in spleen, thymus, prostate, uterus, small intestine, colon and leukocytes. DEVELOPMENTAL STAGE: Cell-cycle regulated: levels are highest early in S phase; not detectable in G2. SIMILARITY: Contains 1 FHA domain. SEQUENCE CAUTION: Sequence=AAC68599.1; Type=Frameshift; Positions=Several; GENE SYNONYMS:MCRS1 INO80Q MSP58. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 462 AA; 51803 MW; F6B7CC8A2AAF16BC CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:6960,
urn:biopax:RelationshipXref:NCBI GENE_10445,
urn:biopax:RelationshipXref:REFSEQ_NP_001012300,
urn:biopax:RelationshipXref:REFSEQ_NP_006328,
urn:biopax:UnificationXref:UNIPROT_O14742,
urn:biopax:UnificationXref:UNIPROT_O75497,
urn:biopax:UnificationXref:UNIPROT_Q6VN53,
urn:biopax:UnificationXref:UNIPROT_Q96EZ8
|
| biopax3:displayName |
MCRS1_HUMAN
|
| biopax3:name |
58 kDa microspherule protein,
Cell cycle-regulated factor p78,
INO80 complex subunit J,
MCRS1,
MCRS2
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:MCRS1_HUMAN_1,
urn:biopax:ModificationFeature:MCRS1_HUMAN_2,
urn:biopax:ModificationFeature:MCRS1_HUMAN_3,
urn:biopax:ModificationFeature:MCRS1_HUMAN_4,
urn:biopax:ModificationFeature:MCRS1_HUMAN_5,
urn:biopax:ModificationFeature:MCRS1_HUMAN_6,
urn:biopax:ModificationFeature:MCRS1_HUMAN_7
|
| biopax3:organism | |
| biopax3:sequence |
MDKDSQGLLDSSLMASGTASRSEDEESLAGQKRASSQALGTIPKRRSSSRFIKRKKFDDELVESSLAKSSTRAKGASGVEPGRCSGSEPSSSEKKKVSKAPSTPVPPSPAPAPGLTKRVKKSKQPLQVTKDLGRWKPADDLLLINAVLQTNDLTSVHLGVKFSCRFTLREVQERWYALLYDPVISKLACQAMRQLHPEAIAAIQSKALFSKAEEQLLSKVGSTSQPTLETFQDLLHRHPDAFYLARTAKALQAHWQLMKQYYLLEDQTVQPLPKGDQVLNFSDAEDLIDDSKLKDMRDEVLEHELMVADRRQKREIRQLEQELHKWQVLVDSITGMSSPDFDNQTLAVLRGRMVRYLMRSREITLGRATKDNQIDVDLSLEGPAWKISRKQGVIKLKNNGDFFIANEGRRPIYIDGRPVLCGSKWRLSNNSVVEIASLRFVFLINQDLIALIRAEAAKITPQ
|
| biopax3:standardName |
Microspherule protein 1
|