| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SUBUNIT: Component of the SCF(FBXW7) complex consisting of CUL1, RBX1, SKP1 and FBXW7. Interacts with PSEN1, cyclin E, NOTCH1 NICD, NOTCH4 NICD and SKP1. Interacts with MYC (when phosphorylated). Isoform 1 interacts with USP28, leading to counteract ubiquitination of MYC. Isoform 4 interacts (via WD repeats) with SV40 large T antigen (via CPD region). Forms a trimeric complex with NOTCH1 and SGK1. SUBCELLULAR LOCATION: Isoform 1: Nucleus, nucleoplasm. SUBCELLULAR LOCATION: Isoform 2: Cytoplasm. SUBCELLULAR LOCATION: Isoform 4: Nucleus, nucleolus. SUBCELLULAR LOCATION: Nucleus (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Archipelago alpha, FBW7alpha, 110K, common; IsoId=Q969H0-1; Sequence=Displayed; Name=2; Synonyms=Archipelago beta, FBW7beta, 69K; IsoId=Q969H0-2; Sequence=VSP_009483, VSP_009484; Name=3; IsoId=Q969H0-3; Sequence=VSP_009481; Note=Incomplete sequence; Name=4; Synonyms=Archipelago gamma, FBW7gamma, Hippocampal; IsoId=Q969H0-4; Sequence=VSP_009482, VSP_009485; TISSUE SPECIFICITY: Isoform 1 is widely expressed. Isoform 4 is expressed in brain. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 1 F-box domain. SIMILARITY: Contains 7 WD repeats. SEQUENCE CAUTION: Sequence=BAA91986.1; Type=Erroneous initiation; GENE SYNONYMS:FBXW7 FBW7 FBX30 SEL10. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 707 AA; 79663 MW; E4A357F76DFD8203 CRC64;
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| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:16712,
urn:biopax:RelationshipXref:NCBI GENE_55294,
urn:biopax:RelationshipXref:REFSEQ_NP_001013433,
urn:biopax:RelationshipXref:REFSEQ_NP_060785,
urn:biopax:RelationshipXref:REFSEQ_NP_361014,
urn:biopax:UnificationXref:UNIPROT_B7ZLP9,
urn:biopax:UnificationXref:UNIPROT_Q68DR0,
urn:biopax:UnificationXref:UNIPROT_Q969H0,
urn:biopax:UnificationXref:UNIPROT_Q96A16,
urn:biopax:UnificationXref:UNIPROT_Q96LE0,
urn:biopax:UnificationXref:UNIPROT_Q96RI2,
urn:biopax:UnificationXref:UNIPROT_Q9NUX6
|
| biopax3:displayName |
FBXW7_HUMAN
|
| biopax3:name |
Archipelago homolog,
F-box and WD-40 domain-containing protein 7,
F-box protein FBX30,
FBXW7,
SEL-10,
hAgo,
hCdc4
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MNQELLSVGSKRRRTGGSLRGNPSSSQVDEEQMNRVVEEEQQQQLRQQEEEHTARNGEVVGVEPRPGGQNDSQQGQLEENNNRFISVDEDSSGNQEEQEEDEEHAGEQDEEDEEEEEMDQESDDFDQSDDSSREDEHTHTNSVTNSSSIVDLPVHQLSSPFYTKTTKMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK
|
| biopax3:standardName |
F-box/WD repeat-containing protein 7
|