| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter. SUBUNIT: TFIIIB comprises at least the TATA-binding protein (TBP) and the B-related factor 1 (BRF1/TFIIIB90). Interacts with BDP1. SUBCELLULAR LOCATION: Nucleus (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=hBRF1; IsoId=Q92994-1; Sequence=Displayed; Name=2; Synonyms=hBRF2; IsoId=Q92994-2; Sequence=VSP_006396, VSP_006397, VSP_006398; Name=3; Synonyms=hBRF3; IsoId=Q92994-3; Sequence=VSP_006396; Name=4; Synonyms=hBRF4; IsoId=Q92994-4; Sequence=VSP_006399, VSP_006400; Name=5; IsoId=Q92994-5; Sequence=VSP_014697; Name=6; IsoId=Q92994-6; Sequence=VSP_043835, VSP_043836; PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the TFIIB family. SIMILARITY: Contains 1 TFIIB-type zinc finger. SEQUENCE CAUTION: Sequence=AAC50170.1; Type=Frameshift; Positions=344, 405; GENE SYNONYMS:BRF1 BRF GTF3B TAF3B2 TAF3C. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 677 AA; 73840 MW; 5866304B879EC1DE CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:11551,
urn:biopax:RelationshipXref:NCBI GENE_2972,
urn:biopax:RelationshipXref:REFSEQ_NP_001229715,
urn:biopax:RelationshipXref:REFSEQ_NP_001229716,
urn:biopax:RelationshipXref:REFSEQ_NP_001229717,
urn:biopax:RelationshipXref:REFSEQ_NP_001229718,
urn:biopax:RelationshipXref:REFSEQ_NP_001229719,
urn:biopax:RelationshipXref:REFSEQ_NP_001510,
urn:biopax:RelationshipXref:REFSEQ_NP_663718,
urn:biopax:UnificationXref:UNIPROT_Q13223,
urn:biopax:UnificationXref:UNIPROT_Q3SYD9,
urn:biopax:UnificationXref:UNIPROT_Q5PR24,
urn:biopax:UnificationXref:UNIPROT_Q6IQ02,
urn:biopax:UnificationXref:UNIPROT_Q92994,
urn:biopax:UnificationXref:UNIPROT_Q96KX3,
urn:biopax:UnificationXref:UNIPROT_Q9HCW6,
urn:biopax:UnificationXref:UNIPROT_Q9HCW7,
urn:biopax:UnificationXref:UNIPROT_Q9HCW8
|
| biopax3:displayName |
TF3B_HUMAN
|
| biopax3:name |
B-related factor 1,
BRF-1,
BRF1,
TAF3B2,
TATA box-binding protein-associated factor, RNA polymerase III, subunit 2,
TFIIIB90,
hBRF,
hTFIIIB90
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MTGRVCRGCGGTDIELDAARGDAVCTACGSVLEDNIIVSEVQFVESSGGGSSAVGQFVSLDGAGKTPTLGGGFHVNLGKESRAQTLQNGRRHIHHLGNQLQLNQHCLDTAFNFFKMAVSRHLTRGRKMAHVIAACLYLVCRTEGTPHMLLDLSDLLQVNVYVLGKTFLLLARELCINAPAIDPCLYIPRFAHLLEFGEKNHEVSMTALRLLQRMKRDWMHTGRRPSGLCGAALLVAARMHDFRRTVKEVISVVKVCESTLRKRLTEFEDTPTSQLTIDEFMKIDLEEECDPPSYTAGQRKLRMKQLEQVLSKKLEEVEGEISSYQDAIEIELENSRPKAKGGLASLAKDGSTEDTASSLCGEEDTEDEELEAAASHLNKDLYRELLGGAPGSSEAAGSPEWGGRPPALGSLLDPLPTAASLGISDSIRECISSQSSDPKDASGDGELDLSGIDDLEIDRYILNESEARVKAELWMRENAEYLREQREKEARIAKEKELGIYKEHKPKKSCKRREPIQASTAREAIEKMLEQKKISSKINYSVLRGLSSAGGGSPHREDAQPEHSASARKLSRRRTPASRSGADPVTSVGKRLRPLVSTQPAKKVATGEALLPSSPTLGAEPARPQAVLVESGPVSYHADEEADEEEPDEEDGEPCVSALQMMGSNDYGCDGDEDDGY
|
| biopax3:standardName |
Transcription factor IIIB 90 kDa subunit
|