| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. SUBUNIT: Interacts with MAP3K1. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q92918-1; Sequence=Displayed; Name=2; IsoId=Q92918-2; Sequence=VSP_040340; TISSUE SPECIFICITY: Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine. SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. SIMILARITY: Contains 1 CNH domain. SIMILARITY: Contains 1 protein kinase domain. GENE SYNONYMS:MAP4K1 HPK1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 833 AA; 91296 MW; 3C98CF01BE42E151 CRC64;
|
| biopax3:xref | |
| biopax3:displayName |
M4K1_HUMAN
|
| biopax3:name |
2.7.11.1,
Hematopoietic progenitor kinase,
MAP4K1,
MAPK/ERK kinase kinase kinase 1,
MEK kinase kinase 1,
MEKKK 1
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:M4K1_HUMAN_1,
urn:biopax:ModificationFeature:M4K1_HUMAN_10,
urn:biopax:ModificationFeature:M4K1_HUMAN_11,
urn:biopax:ModificationFeature:M4K1_HUMAN_12,
urn:biopax:ModificationFeature:M4K1_HUMAN_2,
urn:biopax:ModificationFeature:M4K1_HUMAN_3,
urn:biopax:ModificationFeature:M4K1_HUMAN_4,
urn:biopax:ModificationFeature:M4K1_HUMAN_5,
urn:biopax:ModificationFeature:M4K1_HUMAN_6,
urn:biopax:ModificationFeature:M4K1_HUMAN_7,
urn:biopax:ModificationFeature:M4K1_HUMAN_8,
urn:biopax:ModificationFeature:M4K1_HUMAN_9
|
| biopax3:organism | |
| biopax3:sequence |
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQLSPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
|
| biopax3:standardName |
Mitogen-activated protein kinase kinase kinase kinase 1
|