| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N- smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q92636-1; Sequence=Displayed; Name=2; IsoId=Q92636-2; Sequence=VSP_042036; Note=No experimental confirmation available; TISSUE SPECIFICITY: Ubiquitous. SIMILARITY: Contains 1 BEACH domain. SIMILARITY: Contains 1 GRAM domain. SIMILARITY: Contains 6 WD repeats. GENE SYNONYMS:NSMAF FAN. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 917 AA; 104372 MW; 36498B5A1378E49C CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:8017,
urn:biopax:RelationshipXref:NCBI GENE_8439,
urn:biopax:RelationshipXref:REFSEQ_NP_001138244,
urn:biopax:RelationshipXref:REFSEQ_NP_003571,
urn:biopax:UnificationXref:UNIPROT_B4DFB0,
urn:biopax:UnificationXref:UNIPROT_E9PCH0,
urn:biopax:UnificationXref:UNIPROT_Q8IW26,
urn:biopax:UnificationXref:UNIPROT_Q92636
|
| biopax3:displayName |
FAN_HUMAN
|
| biopax3:name |
Factor associated with N-SMase activation,
Factor associated with neutral sphingomyelinase activation,
NSMAF
|
| biopax3:organism | |
| biopax3:sequence |
MAFIRKKQQEQQLQLYSKERFSLLLLNLEEYYFEQHRANHILHKGSHHERKIRGSLKICSKSVIFEPDSISQPIIKIPLRDCIKIGKHGENGANRHFTKAKSGGISLIFSQVYFIKEHNVVAPYKIERGKMEYVFELDVPGKVEDVVETLLQLHRASCLDKLGDQTAMITAILQSRLARTSFDKNRFQNISEKLHMECKAEMVTPLVTNPGHVCITDTNLYFQPLNGYPKPVVQITLQDVRRIYKRRHGLMPLGLEVFCTEDDLCSDIYLKFYEPQDRDDLYFYIATYLEHHVAEHTAESYMLQWQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWIIHDYSSSELDLSNPGTFRDLSKPVGALNKERLERLLTRYQEMPEPKFMYGSHYSSPGYVLFYLVRIAPEYMLCLQNGRFDNADRMFNSIAETWKNCLDGATDFKELIPEFYGDDVSFLVNSLKLDLGKRQGGQMVDDVELPPWASSPEDFLQKSKDALESNYVSEHLHEWIDLIFGYKQKGSDAVGAHNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFVTPHPRRITPKFKSLSQTSSYNASMADSPGEESFEDLTEESKTLAWNNITKLQLHEHYKIHKEAVTGITVSRNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLYSASWDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDEPQRCFVWDGNSVLSGSQSGELLVWDLLGAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQIIFWKLQY
|
| biopax3:standardName |
Protein FAN
|