| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Component of the BCR(BACURD1) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD13/BACURD1 and RBX1. Interacts with RHOA; with a preferrence for RhoA-GDP. Interacts with POLD2 and PCNA. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in a wide variety of tissues. INDUCTION: By TNF and IL6/interleukin-6. SIMILARITY: Belongs to the BACURD family. SIMILARITY: Contains 1 BTB (POZ) domain. GENE SYNONYMS:KCTD13 BACURD1 PDIP1 POLDIP1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 329 AA; 36357 MW; 17A8AC2DBE81EE78 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:22234,
urn:biopax:RelationshipXref:NCBI GENE_253980,
urn:biopax:RelationshipXref:REFSEQ_NP_849194,
urn:biopax:UnificationXref:UNIPROT_A8K0R5,
urn:biopax:UnificationXref:UNIPROT_Q8WZ19,
urn:biopax:UnificationXref:UNIPROT_Q96P93,
urn:biopax:UnificationXref:UNIPROT_Q96SA1
|
| biopax3:displayName |
BACD1_HUMAN
|
| biopax3:name |
BTB/POZ domain-containing protein KCTD13,
KCTD13,
Polymerase delta-interacting protein 1,
TNFAIP1-like protein,
hBACURD1
|
| biopax3:organism | |
| biopax3:sequence |
MSAEASGPAAAAAPSLEAPKPSGLEPGPAAYGLKPLTPNSKYVKLNVGGSLHYTTLRTLTGQDTMLKAMFSGRVEVLTDAGGWVLIDRSGRHFGTILNYLRDGSVPLPESTRELGELLGEARYYLVQGLIEDCQLALQQKRETLSPLCLIPMVTSPREEQQLLASTSKPVVKLLHNRSNNKYSYTSTSDDNLLKNIELFDKLALRFHGRLLFLKDVLGDEICCWSFYGQGRKIAEVCCTSIVYATEKKQTKVEFPEARIFEETLNILIYETPRGPDPALLEATGGAAGAGGAGRGEDEENREHRVRRIHVRRHITHDERPHGQQIVFKD
|
| biopax3:standardName |
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1
|