| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin. SUBUNIT: Forms homodimer or heterodimer with JUN, JUNB, JUND, CEBPG and ATF2 thereby inhibiting transactivation by JUN, ATF2 and CEBPG (By similarity). Binds multiple DNA elements such as cAMP- response element (CRE) and TPA response element (TRE) either as homodimer or heterodimer (By similarity). Interacts with IRF2BP1. SUBCELLULAR LOCATION: Nucleus (Probable). PTM: Phosphorylation of Thr-148 by MAPK8 in response to different stress conditions such as, UV irradiation, oxidatives stress and anisomycin treatments. PTM: Polyubiquitinated; probably by IRF2BP1. SIMILARITY: Belongs to the bZIP family. ATF subfamily. SIMILARITY: Contains 1 bZIP domain. GENE SYNONYMS:JDP2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 163 AA; 18704 MW; 29C576AF2C574BA8 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:17546,
urn:biopax:RelationshipXref:NCBI GENE_122953,
urn:biopax:RelationshipXref:REFSEQ_NP_001128519,
urn:biopax:RelationshipXref:REFSEQ_NP_001128520,
urn:biopax:RelationshipXref:REFSEQ_NP_001128521,
urn:biopax:RelationshipXref:REFSEQ_NP_569736,
urn:biopax:UnificationXref:UNIPROT_O95430,
urn:biopax:UnificationXref:UNIPROT_Q8WYK2,
urn:biopax:UnificationXref:UNIPROT_Q9UIE4
|
| biopax3:displayName |
JDP2_HUMAN
|
| biopax3:name |
JDP2
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MMPGQIPDPSVTTGSLPGLGPLTGLPSSALTVEELKYADIRNLGAMIAPLHFLEVKLGKRPQPVKSELDEEEERRKRRREKNKVAAARCRNKKKERTEFLQRESERLELMNAELKTQIEELKQERQQLILMLNRHRPTCIVRTDSVKTPESEGNPLLEQLEKK
|
| biopax3:standardName |
Jun dimerization protein 2
|