| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single- stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18- RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH. SUBUNIT: Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. During assembly of the CTF18-RFC complex, CTF18 may first assemble into a subcomplex with RFC2, RFC3, RFC4 and RFC5. CTF18 then interacts directly with CTF8, which in turn interacts with DCC1. The CTF18-RFC complex associates with PCNA and with DNA polymerase POLH. The CTF18-RFC complex does not interact with the Rad9/Rad1/Hus1 complex. CTF18 interacts with SMC1A and RAD21. SUBCELLULAR LOCATION: Nucleus. Note=Associates with chromatin during S phase. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8WVB6-1; Sequence=Displayed; Name=2; IsoId=Q8WVB6-2; Sequence=VSP_034180; Name=3; IsoId=Q8WVB6-3; Sequence=VSP_034179; Note=No experimental confirmation available; SIMILARITY: Belongs to the activator 1 small subunits family. CTF18 subfamily. SEQUENCE CAUTION: Sequence=AAH06437.1; Type=Erroneous initiation; Sequence=BAB15766.1; Type=Erroneous initiation; GENE SYNONYMS:CHTF18 C16orf41 CTF18. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 975 AA; 107383 MW; 1C71B8D71DA916CB CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:18435,
urn:biopax:RelationshipXref:NCBI GENE_63922,
urn:biopax:RelationshipXref:REFSEQ_NP_071375,
urn:biopax:UnificationXref:UNIPROT_B7ZBA2,
urn:biopax:UnificationXref:UNIPROT_D3DU68,
urn:biopax:UnificationXref:UNIPROT_Q7Z6Y4,
urn:biopax:UnificationXref:UNIPROT_Q7Z6Y6,
urn:biopax:UnificationXref:UNIPROT_Q8WVB6,
urn:biopax:UnificationXref:UNIPROT_Q9BR83,
urn:biopax:UnificationXref:UNIPROT_Q9BRG5,
urn:biopax:UnificationXref:UNIPROT_Q9H7K3
|
| biopax3:displayName |
CTF18_HUMAN
|
| biopax3:name |
CHL12,
CHTF18,
hCTF18
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:CTF18_HUMAN_1,
urn:biopax:ModificationFeature:CTF18_HUMAN_2,
urn:biopax:ModificationFeature:CTF18_HUMAN_3,
urn:biopax:ModificationFeature:CTF18_HUMAN_4,
urn:biopax:ModificationFeature:CTF18_HUMAN_5,
urn:biopax:ModificationFeature:CTF18_HUMAN_6,
urn:biopax:ModificationFeature:CTF18_HUMAN_7
|
| biopax3:organism | |
| biopax3:sequence |
MEDYEQELCGVEDDFHNQFAAELEVLAELEGASTPSPSGVPLFTAGRPPRTFEEALARGDAASSPAPAASVGSSQGGARKRQVDADLQPAGSLPHAPRIKRPRLQVVKRLNFRSEEMEEPPPPDSSPTDITPPPSPEDLAELWGHGVSEAAADVGLTRASPAARNPVLRRPPILEDYVHVTSTEGVRAYLVLRADPMAPGVQGSLLHVPWRGGGQLDLLGVSLASLKKQVDGERRERLLQEAQKLSDTLHSLRSGEEEAAQPLGAPEEEPTDGQDASSHCLWVDEFAPRHYTELLSDDFTNRCLLKWLKLWDLVVFGHERPSRKPRPSVEPARVSKEATAPGKWKSHEQVLEEMLEAGLDPSQRPKQKVALLCGPPGLGKTTLAHVIARHAGYSVVEMNASDDRSPEVFRTRIEAATQMESVLGAGGKPNCLVIDEIDGAPVAAINVLLSILNRKGPQEVGPQGPAVPSGGGRRRRAEGGLLMRPIICICNDQFAPSLRQLKQQAFLLHFPPTLPSRLVQRLQEVSLRQGMRADPGVLAALCEKTDNDIRACINTLQFLYSRGQRELSVRDVQATRVGLKDQRRGLFSVWQEVFQLPRAQRRRVGQDPALPADTLLLGDGDAGSLTSASQRFYRVLHAAASAGEHEKVVQGLFDNFLRLRLRDSSLGAVCVALDWLAFDDLLAGAAHHSQSFQLLRYPPFLPVAFHVLFASSHTPRITFPSSQQEAQNRMSQMRNLIQTLVSGIAPATRSRATPQALLLDALCLLLDILAPKLRPVSTQLYSTREKQQLASLVGTMLAYSLTYRQERTPDGQYIYRLEPNVEELCRFPELPARKPLTYQTKQLIAREIEVEKMRRAEASARVENSPQVDGSPPGLEGLLGGIGEKGVHRPAPRNHEQRLEHIMRRAAREEQPEKDFFGRVVVRSTAVPSAGDTAPEQDSVERRMGTAVGRSEVWFRFNEGVSNAVRRSLYIRDLL
|
| biopax3:standardName |
Chromosome transmission fidelity protein 18 homolog
|