| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: In vitro, phosphorylates MBP. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. ENZYME REGULATION: Activated by threonine and tyrosine phosphorylation. Inhibited by dual specificity phosphatases, such as DUSP1 (By similarity). SUBUNIT: Interacts with CSK/c-Src, ABL1, RET and TGFB1I1. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8TD08-1; Sequence=Displayed; Name=2; Synonyms=Erk8 delta; IsoId=Q8TD08-2; Sequence=VSP_017919, VSP_017920; Note=Appears not to be a CSK- and RET-dependent activated kinase; Name=3; IsoId=Q8TD08-3; Sequence=VSP_017918, VSP_017921; Note=No experimental confirmation available; TISSUE SPECIFICITY: Widely expressed with a maximal expression in lung and kidney. DOMAIN: The N-terminal region (1-20) is the minimal region necessary for ubiquitination and further proteasomal degradation (By similarity). DOMAIN: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. PTM: Dually phosphorylated on Thr-175 and Tyr-177, which activates the enzyme. Autophosphorylated on threonine and tyrosine residues in vitro. PTM: Ubiquitinated. Ubiquitination may allow its tight kinase activity regulation and rapid turnover. May be ubiquitinated by a SCF E3 ligase (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. SIMILARITY: Contains 1 protein kinase domain. GENE SYNONYMS:MAPK15 ERK7 ERK8. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 544 AA; 59832 MW; 758E0E3B9654AAC5 CRC64;
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| biopax3:xref | |
| biopax3:displayName |
MK15_HUMAN
|
| biopax3:name |
2.7.11.24,
ERK-7,
ERK-8,
Extracellular signal-regulated kinase 7,
Extracellular signal-regulated kinase 8,
MAP kinase 15,
MAPK 15,
MAPK15
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MCTVVDPRIVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPNIISLLDVIRAENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGCRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILECGGSSGTSREKGPEGVSPSQAHLHKPRADPQLPSRTPVQGPRPRPQSSPGHDPAEHESPRAAKNVPRQNSAPLLQTALLGNGERPPGAKEAPPLTLSLVKPSGRGAAPSLTSQAAAQVANQALIRGDWNRGGGVRVASVQQVPPRLPPEARPGRRMFSTSALQGAQGGARALLGGYSQAYGTVCHSALGHLPLLEGHHV
|
| biopax3:standardName |
Mitogen-activated protein kinase 15
|