| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle. SUBUNIT: Directly interacts with tubulin-gamma; this interaction determines centrosomal localization. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. Note=Localized at the center of the radial microtubule array in interphase and at the spindle poles during various stages of mitosis. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8NHQ1-1; Sequence=Displayed; Name=2; IsoId=Q8NHQ1-2; Sequence=VSP_012746, VSP_012747; Name=3; IsoId=Q8NHQ1-3; Sequence=VSP_012745; Name=4; IsoId=Q8NHQ1-4; Sequence=VSP_042140; Note=No experimental confirmation available; Name=5; IsoId=Q8NHQ1-5; Sequence=VSP_042140, VSP_042141; Note=No experimental confirmation available; DOMAIN: The coiled-coil domains may be important for tubulin- gamma-binding and hence for centrosomal localization. SIMILARITY: Contains 1 TPR repeat. GENE SYNONYMS:CEP70 BITE. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 597 AA; 69752 MW; 345EEEB9B1F0D6C7 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:29972,
urn:biopax:RelationshipXref:NCBI GENE_80321,
urn:biopax:RelationshipXref:REFSEQ_NP_077817,
urn:biopax:UnificationXref:UNIPROT_B7Z5I8,
urn:biopax:UnificationXref:UNIPROT_B7Z7E8,
urn:biopax:UnificationXref:UNIPROT_D3DNE9,
urn:biopax:UnificationXref:UNIPROT_F5GZX8,
urn:biopax:UnificationXref:UNIPROT_Q8NHQ1,
urn:biopax:UnificationXref:UNIPROT_Q96B31,
urn:biopax:UnificationXref:UNIPROT_Q9H2C3,
urn:biopax:UnificationXref:UNIPROT_Q9H2Z1,
urn:biopax:UnificationXref:UNIPROT_Q9H940
|
| biopax3:displayName |
CEP70_HUMAN
|
| biopax3:name |
CEP70,
Cep70,
p10-binding protein
|
| biopax3:organism | |
| biopax3:sequence |
MFPVAPKPQDSSQPSDRLMTEKQQEEAEWESINVLLMMHGLKPLSLVKRTDLKDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSINSIIHNPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHLVPVIEMWADQLTSLKDLYKSLKTLSAELVPWLNLKKQDENEGIKVEDLLFIVDTMLEEVENKEKDSNMPHFQTLQAIVSHFQKLFDVPSLNGVYPRMNEVYTRLGEMNNAVRNLQELLELDSSSSLCVLVSTVGKLCRLINEDVNEQVMQVLGPEDLQSIIYKLEEHEEFFPAFQAFTNDLLEILEIDDLDAIVPAVKKLKVLSY
|
| biopax3:standardName |
Centrosomal protein of 70 kDa
|