| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: May play a role in spermatogenesis (By similarity). May be involved in differentiation or function of ciliated cells. SUBUNIT: Interacts with alpha-tubulin (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). Nucleus. Cytoplasm. Note=Localizes to the manchette in elongating spermatids (By similarity). Predominantly perinuclear in bronchial epithelial cells but also detected in the nucleus in some primary epithelial cells and in a number of cell lines. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=NYD-SP22 v1; IsoId=Q8NCR6-1; Sequence=Displayed; Name=2; IsoId=Q8NCR6-2; Sequence=VSP_027169, VSP_027171; Note=No experimental confirmation available; Name=3; Synonyms=NYD-SP22 v3; IsoId=Q8NCR6-3; Sequence=VSP_027169, VSP_027170; Note=No experimental confirmation available. Ref.2 (AAK53410) sequence is in conflict in position: 61:C->Y; Name=4; Synonyms=CBE1 ORF2; IsoId=Q8NCR6-4; Sequence=VSP_027169, VSP_042861; Name=5; Synonyms=CBE1 ORF1, NYD-SP22 v2; IsoId=Q8NCR6-5; Sequence=VSP_027169; TISSUE SPECIFICITY: Expressed in epithelial cells of nasal polyps and in intact epithelium of bronchial biopsies from subjects with and without asthma. Strong expression in columnar cells with little or no expression in basal epithelial cells along the basement membrane. Strongly expressed in ciliated epithelial cells with lower levels in goblet cells (at protein level). DEVELOPMENTAL STAGE: Expressed during in vitro differentiation of bronchial epithelial cells. In fetal lung, expression is barely detectable at 10 weeks post-conception but is strong in airway epithelium at 12.3 weeks post-conception. INDUCTION: Down-regulated by IL13. SIMILARITY: Belongs to the SMRP1 family. GENE SYNONYMS:SMRP1 C9orf24 CBE1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 262 AA; 30167 MW; 6F1FA3A06401BFEB CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:19919,
urn:biopax:RelationshipXref:NCBI GENE_84688,
urn:biopax:RelationshipXref:REFSEQ_NP_001239124,
urn:biopax:RelationshipXref:REFSEQ_NP_115985,
urn:biopax:RelationshipXref:REFSEQ_NP_671697,
urn:biopax:RelationshipXref:REFSEQ_NP_671698,
urn:biopax:UnificationXref:UNIPROT_Q5T598,
urn:biopax:UnificationXref:UNIPROT_Q5T599,
urn:biopax:UnificationXref:UNIPROT_Q5T5A0,
urn:biopax:UnificationXref:UNIPROT_Q8N9G4,
urn:biopax:UnificationXref:UNIPROT_Q8NCR6,
urn:biopax:UnificationXref:UNIPROT_Q96KD1,
urn:biopax:UnificationXref:UNIPROT_Q96LN1
|
| biopax3:displayName |
SMRP1_HUMAN
|
| biopax3:name |
Ciliated bronchial epithelial protein 1,
SMRP1,
Testis development protein NYD-SP22
|
| biopax3:organism | |
| biopax3:sequence |
MFLFSRKTRTPISTYSDSYRAPTSIKEVYKDPPLCAWEANKFLTPGLTHTMERHVDPEALQKMAKCAVQDYTYRGSISGHPYLPEKYWLSQEEADKCSPNYLGSDWYNTWRMEPYNSSCCNKYTTYLPRLPKEARMETAVRGMPLECPPRPERLNAYEREVMVNMLNSLSRNQQLPRITPRCGCVDPLPGRLPFHGYESACSGRHYCLRGMDYYASGAPCTDRRLRPWCREQPTMCTSLRAPARNAVCCYNSPAVILPISEP
|
| biopax3:standardName |
Spermatid-specific manchette-related protein 1
|