| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). SUBUNIT: Interacts with ARF1. Interacts with the COPI coat proteins, KDELR1 and TMED2. The interaction with TMED2 inhibits the GAP activity (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Golgi apparatus (By similarity). Note=Associates with the Golgi complex (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8N6T3-1; Sequence=Displayed; Name=2; IsoId=Q8N6T3-2; Sequence=VSP_000298, VSP_000299; Note=No experimental confirmation available; Name=3; IsoId=Q8N6T3-3; Sequence=VSP_021818; DOMAIN: The region downstream of Arf-GAP domain is essential to GAP activity in vivo. This region may be required for its targeting to Golgi membranes (By similarity). SIMILARITY: Contains 1 Arf-GAP domain. SEQUENCE CAUTION: Sequence=BAB55009.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB55113.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAB70901.1; Type=Miscellaneous discrepancy; Note=Intron retention; GENE SYNONYMS:ARFGAP1 ARF1GAP. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 406 AA; 44668 MW; CAE41828DE660621 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:15852,
urn:biopax:RelationshipXref:NCBI GENE_55738,
urn:biopax:RelationshipXref:REFSEQ_NP_060679,
urn:biopax:RelationshipXref:REFSEQ_NP_783202,
urn:biopax:UnificationXref:UNIPROT_B7ZBI3,
urn:biopax:UnificationXref:UNIPROT_E1P5I9,
urn:biopax:UnificationXref:UNIPROT_Q6PK71,
urn:biopax:UnificationXref:UNIPROT_Q8N6T3,
urn:biopax:UnificationXref:UNIPROT_Q96KC4,
urn:biopax:UnificationXref:UNIPROT_Q96T02,
urn:biopax:UnificationXref:UNIPROT_Q9NSU3,
urn:biopax:UnificationXref:UNIPROT_Q9NVF6,
urn:biopax:UnificationXref:UNIPROT_Q9UIL0
|
| biopax3:displayName |
ARFG1_HUMAN
|
| biopax3:name |
ADP-ribosylation factor 1 GTPase-activating protein,
ARF GAP 1,
ARF1 GAP,
ARF1-directed GTPase-activating protein,
ARFGAP1
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:ARFG1_HUMAN_1,
urn:biopax:ModificationFeature:ARFG1_HUMAN_2,
urn:biopax:ModificationFeature:ARFG1_HUMAN_3,
urn:biopax:ModificationFeature:ARFG1_HUMAN_4,
urn:biopax:ModificationFeature:ARFG1_HUMAN_5,
urn:biopax:ModificationFeature:ARFG1_HUMAN_6,
urn:biopax:ModificationFeature:ARFG1_HUMAN_7,
urn:biopax:ModificationFeature:ARFG1_HUMAN_8,
urn:biopax:ModificationFeature:ARFG1_HUMAN_9
|
| biopax3:organism | |
| biopax3:sequence |
MASPRTRKVLKEVRVQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLESQEDYDPCWSLQEKYNSRAAALFRDKVVALAEGREWSLESSPAQNWTPPQPRTLPSMVHRVSGQPQSVTASSDKAFEDWLNDDLGSYQGAQGNRYVGFGNTPPPQKKEDDFLNNAMSSLYSGWSSFTTGASRFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGKIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEGPLDSPSEGHSYQNSGLDHFQNSNIDQSFWETFGSAEPTKTRKSPSSDSWTCADTSTERRSSDSWEVWGSASTNRNSNSDGGEGGEGTKKAVPPAVPTDDGWDNQNW
|
| biopax3:standardName |
ADP-ribosylation factor GTPase-activating protein 1
|