| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity). SUBUNIT: Interacts with CDK5R1 and EPHA4; activated by EPHA4 through the CDK5 kinase (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane (By similarity). Cell projection, growth cone (By similarity). Note=Associated with membranes. Localizes to axonal growth cones (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N5V2-1; Sequence=Displayed; Name=2; IsoId=Q8N5V2-2; Sequence=VSP_020259, VSP_020260, VSP_020261; Note=No experimental confirmation available; TISSUE SPECIFICITY: Highly expressed in brain specifically in caudate nucleus and to a lower extent in amygdala and hippocampus. Also detected in lung. DOMAIN: The DH domain and the PH domain are both required to mediate interaction with EPHA4 (By similarity). PTM: Src-dependent phosphorylation at Tyr-179 upon EPHA4 activation increases the guanine exchange factor activity toward RHOA. Phosphorylation by CDK5 upon EPHA4 activation by EFNA1 may regulate dendritic spine morphogenesis (By similarity). SIMILARITY: Contains 1 DH (DBL-homology) domain. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 SH3 domain. SEQUENCE CAUTION: Sequence=AAH73962.1; Type=Erroneous initiation; Sequence=AAX93288.1; Type=Erroneous initiation; Sequence=CAC00686.1; Type=Frameshift; Positions=156; GENE SYNONYMS:NGEF. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 710 AA; 82496 MW; 82A4CA71D4E7AE6E CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:7807,
urn:biopax:RelationshipXref:NCBI GENE_25791,
urn:biopax:RelationshipXref:REFSEQ_NP_001107562,
urn:biopax:RelationshipXref:REFSEQ_NP_062824,
urn:biopax:UnificationXref:UNIPROT_B9A045,
urn:biopax:UnificationXref:UNIPROT_Q53QQ4,
urn:biopax:UnificationXref:UNIPROT_Q53ST7,
urn:biopax:UnificationXref:UNIPROT_Q6GMQ5,
urn:biopax:UnificationXref:UNIPROT_Q8N5V2,
urn:biopax:UnificationXref:UNIPROT_Q9NQD6
|
| biopax3:displayName |
NGEF_HUMAN
|
| biopax3:name |
Eph-interacting exchange protein,
NGEF,
Neuronal guanine nucleotide exchange factor
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
METRESEDLEKTRRKSASDQWNTDNEPAKVKPELLPEKEETSQADQDIQDKEPHCHIPIKRNSIFNRSIRRKSKAKARDNPERNASCLADSQDNGKSVNEPLTLNIPWSRMPPCRTAMQTDPGAQEMSESSSTPGNGATPEEWPALADSPTTLTEALRMIHPIPADSWRNLIEQIGLLYQEYRDKSTLQEIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSMTEEILNPKIRSQNLKECFRVHKMDDPQRSQNKDRRKLGSRNRQ
|
| biopax3:standardName |
Ephexin-1
|