| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow. CATALYTIC ACTIVITY: 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. COFACTOR: Binds 3 calcium ions per subunit. Two of the calcium ions are bound to the C2 domain (Probable). ENZYME REGULATION: Strongly activated by phosphatidic acid. Inhibited by phosphatidylethanolamine (PtdEtn), phosphatidylcholine (PtdCho), sphingomyelin and phosphatidylserine (PtdSer). BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=105.3 uM for PIP2; Vmax=28.5 umol/min/mg enzyme; SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. Cytoplasm. Cleavage furrow. Note=Localizes at the cleavage furrow during cytokinesis. TISSUE SPECIFICITY: Present in corneal epithelial cells (at protein level). INDUCTION: Down-regulated by Ca(2+) and cAMP. DOMAIN: The C2 domain is a Ca(2+)-dependent membrane-targeting module. DOMAIN: The PH domain mediates interaction with the surface membrane by binding to PIP2. SIMILARITY: Contains 1 C2 domain. SIMILARITY: Contains 3 EF-hand domains. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 PI-PLC X-box domain. SIMILARITY: Contains 1 PI-PLC Y-box domain. GENE SYNONYMS:PLCD3 KIAA1964. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 789 AA; 89258 MW; C6901404D2C9D070 CRC64;
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| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:9061,
urn:biopax:RelationshipXref:NCBI GENE_113026,
urn:biopax:RelationshipXref:REFSEQ_NP_588614,
urn:biopax:UnificationXref:UNIPROT_Q8N3E9,
urn:biopax:UnificationXref:UNIPROT_Q8TEC1,
urn:biopax:UnificationXref:UNIPROT_Q8TF37,
urn:biopax:UnificationXref:UNIPROT_Q96FL6
|
| biopax3:displayName |
PLCD3_HUMAN
|
| biopax3:name |
3.1.4.11,
PLC-delta-3,
PLCD3,
Phosphoinositide phospholipase C-delta-3,
Phospholipase C-delta-3
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MLCGRWRRCRRPPEEPPVAAQVAAQVAAPVALPSPPTPSDGGTKRPGLRALKKMGLTEDEDVRAMLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAVREGHQSEGLRRFGGAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKLRARLDAMSQRERLDHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECDHSNNDRLEGAEIEEFLRRLLKRPELEEIFHQYSGEDRVLSAPELLEFLEDQGEEGATLARAQQLIQTYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEELPSPEQLKGRVLVKGKKLPAARSEDGRALSDREEEEEDDEEEEEEVEAAAQRRLAKQISPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHNARQLTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPACLRQPDSTFDPEYPGPPRTTLSIQVLTAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCARQETDYVLNNGFNPRWGQTLQFQLRAPELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLFIQIRIQRS
|
| biopax3:standardName |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3
|