| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with TRAF6, IRAK1, MAP3K14 and MAP3K7. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Alpha, A; IsoId=Q8N2H9-1; Sequence=Displayed; Name=2; Synonyms=Beta, B; IsoId=Q8N2H9-2; Sequence=VSP_008640; Name=3; IsoId=Q8N2H9-3; Sequence=VSP_008639; Note=No experimental confirmation available; Name=4; IsoId=Q8N2H9-4; Sequence=VSP_008641, VSP_008642; Note=No experimental confirmation available; TISSUE SPECIFICITY: Highly expressed in brain, heart and testis, and at lower level in kidney, liver, lung, placenta, small intestine, spleen and stomach. Isoform 1 is not expressed in lung. PTM: Phosphorylated by IRAK1 enhancing its E3 ligase activity. SIMILARITY: Belongs to the pellino family. SEQUENCE CAUTION: Sequence=BAC11499.1; Type=Erroneous initiation; GENE SYNONYMS:PELI3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 469 AA; 50755 MW; 7E14D1405B023F96 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:30010,
urn:biopax:RelationshipXref:NCBI GENE_246330,
urn:biopax:RelationshipXref:REFSEQ_NP_001091980,
urn:biopax:RelationshipXref:REFSEQ_NP_001230064,
urn:biopax:RelationshipXref:REFSEQ_NP_001230065,
urn:biopax:RelationshipXref:REFSEQ_NP_659502,
urn:biopax:UnificationXref:UNIPROT_Q8N2H9,
urn:biopax:UnificationXref:UNIPROT_Q8N3E1,
urn:biopax:UnificationXref:UNIPROT_Q8N9Q6,
urn:biopax:UnificationXref:UNIPROT_Q8TAW7,
urn:biopax:UnificationXref:UNIPROT_Q8TED5
|
| biopax3:displayName |
PELI3_HUMAN
|
| biopax3:name |
6.3.2.-,
PELI3,
Pellino-3
|
| biopax3:organism | |
| biopax3:sequence |
MVLEGNPEVGSPRTSDLQHRGNKGSCVLSSPGEDAQPGEEPIKYGELIVLGCCEEGGEETEAQRGEVTGPRAHSCYNGCLASGDKGRRRSRLALSRRSHANGVKPDVMHHISTPLVSKALSNRGQHSISYTLSRSHSVIVEYTHDSDTDMFQIGRSTENMIDFVVTDTSPGGGAAEGPSAQSTISRYACRILCDRRPPYTARIYAAGFDASSNIFLGERAAKWRTPDGLMDGLTTNGVLVMHPAGGFSEDSAPGVWREISVCGNVYTLRDSRSAQQRGKLVENESNVLQDGSLIDLCGATLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPARGRTAPDKQQPWVYVRCGHVHGYHGWGCRRERGPQERECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGHVCSEKTARYWAQTPLPHGTHAFHAACPFCGAWLTGEHGCVRLIFQGPLD
|
| biopax3:standardName |
E3 ubiquitin-protein ligase pellino homolog 3
|