| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Induces an innate immunity to viral infections by preventing the accumulation of viral RNAs in the cytoplasm. Seems to recruit the RNA processing exosome to degrade the target RNAs. Inhibits Moloney murine leukemia virus, alphavirus and filovirus replication. SUBUNIT: Interacts with EXOSC5. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner. TISSUE SPECIFICITY: Expressed in the kidney and liver. DOMAIN: The second and fourth zinc fingers are involved in binding to specific viral RNAs. SIMILARITY: Contains 4 C3H1-type zinc fingers. SIMILARITY: Contains 1 WWE domain. GENE SYNONYMS:Zc3hav1 Zap. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 776 AA; 86771 MW; D13F61A9F8E5B552 CRC64;
|
| biopax3:xref | |
| biopax3:displayName |
ZCCHV_RAT
|
| biopax3:name |
ADP-ribosyltransferase diphtheria toxin-like 13,
ARTD13,
ZAP,
Zc3hav1,
Zinc finger antiviral protein,
rZAP
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:ZCCHV_RAT_1,
urn:biopax:ModificationFeature:ZCCHV_RAT_10,
urn:biopax:ModificationFeature:ZCCHV_RAT_11,
urn:biopax:ModificationFeature:ZCCHV_RAT_2,
urn:biopax:ModificationFeature:ZCCHV_RAT_3,
urn:biopax:ModificationFeature:ZCCHV_RAT_4,
urn:biopax:ModificationFeature:ZCCHV_RAT_5,
urn:biopax:ModificationFeature:ZCCHV_RAT_6,
urn:biopax:ModificationFeature:ZCCHV_RAT_7,
urn:biopax:ModificationFeature:ZCCHV_RAT_8,
urn:biopax:ModificationFeature:ZCCHV_RAT_9
|
| biopax3:organism | |
| biopax3:sequence |
MADPGVCCFITKILCAHGGRMTLEELLGEIRLPEAQLYELLETAGPDRFVLLETGGQAGITRSVVATTRARVCRRKYCQRPCDSLHLCKLNLLGRCHYAQSQRNLCKYSHDVLSEQNFQILKNHELSGLNQEELACLLVQSDPFFLPEICKSYKGEGRKQTCGQPQPCERLHICEHFTRGNCSYLNCLRSHNLMDRKVLTIMREHGLSPDVVQNIQDICNNKHARRNPPGTRAAHPHRRGGAHRDRSKSRDRFLHNSLEFLSPVVSPLGSGPPSPDVTSCKDSLEDVSVDVTQKFKYLGTHDRAQLSPVSSKAAGVQGPSQMRASQEFSEDGNLDDIFSRNRSDSSSSRASAAKVAQRNEAVAMKMGMEVKGKKEAPDIDRVPFLNSYIDGVTMEKASVSGIPGKKFTANDLENLLLLNDTWKNVAKPQDLQTTGRITDSGQDKAFLQNKYGGNPVWASASTHNAPNGSSQIMDETPNVSKSSTSGFAIKPAIAGGKEAVYSGVQSPRSQVLAVPGEATTPVQSNRLPQSPLSSSSHRAAASGSPGKNSTHTSVSPAIESSRMTSDPDEYLLRYILNPLFRMDNHGPKEICQDHLYKGCQQSHCDRSHFHLPYRWQMFVYTTWRDFQDMESIEQAYCDPHVELILIENHQINFQKMTCDSYPIRRLSTPSYEEKPLSAVFATKWIWYWKNEFNEYIQYGNESPGHTSSDINSAYLESFFQSCPRGVLPFQAGSQKYELSFQGMIQTNIASKTQRHVVRRPVFVSSNDVEQKRRGPE
|
| biopax3:standardName |
Zinc finger CCCH-type antiviral protein 1
|