| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor- protein] phosphate. COFACTOR: Magnesium or manganese. SUBUNIT: Binds the type 2 receptor protein ACVR2A (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity). TISSUE SPECIFICITY: Expressed in interdigital regions in developing limb buds. SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. SIMILARITY: Contains 1 GS domain. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=AK142396; Type=Frameshift; Positions=236; GENE SYNONYMS:Acvr1c Alk7. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 493 AA; 54700 MW; CB9BE5E368CA2D2F CRC64;
|
| biopax3:xref | |
| biopax3:displayName |
ACV1C_MOUSE
|
| biopax3:name |
2.7.11.30,
ACTR-IC,
ALK-7,
Activin receptor type IC,
Activin receptor-like kinase 7,
Acvr1c
|
| biopax3:organism | |
| biopax3:sequence |
MTPARGSALSLALLLVALAADLAAGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAPRLGPTELTVVITVPVCLLSIAAMLTIWACQDRQCTYRKTKRHNVEEALAEYSLVNAGKTLKDLIYDATASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMVKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCDTCAIADLGLAVKHDSIMNTIDIPQNPKVGTKRYMAPEMLDDTMNLSIFESFKRADIYSVGLVYWEIARRCSVGGVVEEYQLPYYDMVPSDPSIEEMRKVVCDQKLRPNLPNQWQSCEALRVMGRIMRECWYANGAARLTALRVKKTISQLCVKEDCKA
|
| biopax3:standardName |
Activin receptor type-1C
|