| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence- specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. SUBUNIT: Interacts with HRS, RXRA, SUMO2, HDAC2, RB1 and STAT3. Interacts with PI3K, SRC and EGFR in cytoplasm. Interacts with ESR1 and ESR2 and this interaction is enhanced by 17-beta- estradiol. Interacts with CREBBP, EP300, AR and NR3C1 in a ligand- dependent manner. Forms two complexes in the presence of 17-beta- estradiol; one with SRC and ESR1 and another with LCK and ESR1. Interacts with histone H1 and H3 with a greater affinity for H1. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Also found associated with the plasma membrane. Mainly in cytoplasm in a subset of breast tumors. Localization is widely deregulated in endometrial cancers with predominantly cytoplasm localization in high-grade endometrial tumors. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8IZL8-1; Sequence=Displayed; Name=2; IsoId=Q8IZL8-2; Sequence=VSP_020880; TISSUE SPECIFICITY: Isoform 2 is expressed in breast cancer cell lines. Isoform 1 is widely expressed. DOMAIN: The Glu-rich region mediates histones interaction. DOMAIN: The Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are required for the association with nuclear receptor ESR1. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SEQUENCE CAUTION: Sequence=AAC17708.2; Type=Frameshift; Positions=656, 672; GENE SYNONYMS:PELP1 HMX3 MNAR. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 1130 AA; 119700 MW; 7B0DEE7A198DA9A6 CRC64;
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| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:30134,
urn:biopax:RelationshipXref:NCBI GENE_27043,
urn:biopax:RelationshipXref:REFSEQ_NP_055204,
urn:biopax:UnificationXref:UNIPROT_O15450,
urn:biopax:UnificationXref:UNIPROT_Q5EGN3,
urn:biopax:UnificationXref:UNIPROT_Q6NTE6,
urn:biopax:UnificationXref:UNIPROT_Q8IZL8,
urn:biopax:UnificationXref:UNIPROT_Q96FT1,
urn:biopax:UnificationXref:UNIPROT_Q9BU60
|
| biopax3:displayName |
PELP1_HUMAN
|
| biopax3:name |
Modulator of non-genomic activity of estrogen receptor,
PELP1,
Transcription factor HMX3
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:PELP1_HUMAN_1,
urn:biopax:ModificationFeature:PELP1_HUMAN_10,
urn:biopax:ModificationFeature:PELP1_HUMAN_11,
urn:biopax:ModificationFeature:PELP1_HUMAN_2,
urn:biopax:ModificationFeature:PELP1_HUMAN_3,
urn:biopax:ModificationFeature:PELP1_HUMAN_4,
urn:biopax:ModificationFeature:PELP1_HUMAN_5,
urn:biopax:ModificationFeature:PELP1_HUMAN_6,
urn:biopax:ModificationFeature:PELP1_HUMAN_7,
urn:biopax:ModificationFeature:PELP1_HUMAN_8,
urn:biopax:ModificationFeature:PELP1_HUMAN_9
|
| biopax3:organism | |
| biopax3:sequence |
MAAAVLSGPSAGSAAGVPGGTGGLSAVSSGPRLRLLLLESVSGLLQPRTGSAVAPVHPPNRSAPHLPGLMCLLRLHGSVGGAQNLSALGALVSLSNARLSSIKTRFEGLCLLSLLVGESPTELFQQHCVSWLRSIQQVLQTQDPPATMELAVAVLRDLLRYAAQLPALFRDISMNHLPGLLTSLLGLRPECEQSALEGMKACMTYFPRACGSLKGKLASFFLSRVDALSPQLQQLACECYSRLPSLGAGFSQGLKHTESWEQELHSLLASLHTLLGALYEGAETAPVQNEGPGVEMLLSSEDGDAHVLLQLRQRFSGLARCLGLMLSSEFGAPVSVPVQEILDFICRTLSVSSKNISLHGDGPLRLLLLPSIHLEALDLLSALILACGSRLLRFGILIGRLLPQVLNSWSIGRDSLSPGQERPYSTVRTKVYAILELWVQVCGASAGMLQGGASGEALLTHLLSDISPPADALKLRSPRGSPDGSLQTGKPSAPKKLKLDVGEAMAPPSHRKGDSNANSDVCAAALRGLSRTILMCGPLIKEETHRRLHDLVLPLVMGVQQGEVLGSSPYTSSRCRRELYCLLLALLLAPSPRCPPPLACALQAFSLGQREDSLEVSSFCSEALVTCAALTHPRVPPLQPMGPTCPTPAPVPPPEAPSPFRAPPFHPPGPMPSVGSMPSAGPMPSAGPMPSAGPVPSARPGPPTTANHLGLSVPGLVSVPPRLLPGPENHRAGSNEDPILAPSGTPPPTIPPDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLPPLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPGPLPPPPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAEEEMETETEAEALQEKEQDDTAAMLADFIDCPPDDEKPPPPTEPDS
|
| biopax3:standardName |
Proline-, glutamic acid- and leucine-rich protein 1
|