| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity. SUBUNIT: Interacts with the cytoplasmic part of DCC (By similarity). Interacts with GNAI2 via its cytoplasmic part. Interacts (via death domain) with DAPK1 (via death domain). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Note=Associated with lipid raft. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8IZJ1-1; Sequence=Displayed; Name=2; IsoId=Q8IZJ1-2; Sequence=VSP_011698; TISSUE SPECIFICITY: Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues. INDUCTION: By p53/TP53. PTM: Phosphorylated on cytoplasmic tyrosine residues (By similarity). PTM: Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis. PTM: Palmitoylation target the protein to the lipid rafts, and is required for pro-apoptotic activity. MISCELLANEOUS: Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers. SIMILARITY: Belongs to the unc-5 family. SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 1 Ig-like (immunoglobulin-like) domain. SIMILARITY: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. SIMILARITY: Contains 2 TSP type-1 domains. SIMILARITY: Contains 1 ZU5 domain. SEQUENCE CAUTION: Sequence=BAB14276.1; Type=Erroneous initiation; Sequence=BAC04382.1; Type=Erroneous initiation; GENE SYNONYMS:UNC5B P53RDL1 UNC5H2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 945 AA; 103638 MW; 56064E335F323447 CRC64;
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| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:12568,
urn:biopax:RelationshipXref:NCBI GENE_219699,
urn:biopax:RelationshipXref:REFSEQ_NP_001231818,
urn:biopax:RelationshipXref:REFSEQ_NP_734465,
urn:biopax:UnificationXref:UNIPROT_Q5T3R9,
urn:biopax:UnificationXref:UNIPROT_Q5T3S0,
urn:biopax:UnificationXref:UNIPROT_Q86SN3,
urn:biopax:UnificationXref:UNIPROT_Q8IZJ1,
urn:biopax:UnificationXref:UNIPROT_Q8N1Y2,
urn:biopax:UnificationXref:UNIPROT_Q9H9F3
|
| biopax3:displayName |
UNC5B_HUMAN
|
| biopax3:name |
Protein unc-5 homolog 2,
Protein unc-5 homolog B,
UNC5B,
p53-regulated receptor for death and life protein 1
|
| biopax3:organism | |
| biopax3:sequence |
MGARSGARGALLLALLLCWDPRLSQAGTDSGSEVLPDSFPSAPAEPLPYFLQEPQDAYIVKNKPVELRCRAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIVAKRRSTTATVIVYVNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICPVDGAWTEWSKWSACSTECAHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCMQNKKTLSDPNSHLLEASGDAALYAGLVVAIFVVVAILMAVGVVVYRRNCRDFDTDITDSSAALTGGFHPVNFKTARPSNPQLLHPSVPPDLTASAGIYRGPVYALQDSTDKIPMTNSPLLDPLPSLKVKVYSSSTTGSGPGLADGADLLGVLPPGTYPSDFARDTHFLHLRSASLGSQQLLGLPRDPGSSVSGTFGCLGGRLSIPGTGVSLLVPNGAIPQGKFYEMYLLINKAESTLPLSEGTQTVLSPSVTCGPTGLLLCRPVILTMPHCAEVSARDWIFQLKTQAHQGHWEEVVTLDEETLNTPCYCQLEPRACHILLDQLGTYVFTGESYSRSAVKRLQLAVFAPALCTSLEYSLRVYCLEDTPVALKEVLELERTLGGYLVEEPKPLMFKDSYHNLRLSLHDLPHAHWRSKLLAKYQEIPFYHIWSGSQKALHCTFTLERHSLASTELTCKICVRQVEGEGQIFQLHTTLAETPAGSLDTLCSAPGSTVTTQLGPYAFKIPLSIRQKICNSLDAPNSRGNDWRMLAQKLSMDRYLNYFATKASPTGVILDLWEALQQDDGDLNSLASALEEMGKSEMLVAVATDGDC
|
| biopax3:standardName |
Netrin receptor UNC5B
|