| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression (By similarity). SUBUNIT: Interacts with MET; oligomerization increases affinity for MET (By similarity). SUBCELLULAR LOCATION: Secreted (Potential). Apical cell membrane (By similarity). Basolateral cell membrane (By similarity). Cell projection, microvillus membrane (By similarity). TISSUE SPECIFICITY: Highly expressed in kidney. Up-regulated in renal tissues during renal injury. SEQUENCE CAUTION: Sequence=AAH26367.1; Type=Erroneous initiation; WEB RESOURCE: Name=Mucin database; URL="http://www.medkem.gu.se/mucinbiology/databases/"; GENE SYNONYMS:Muc20. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 656 AA; 68720 MW; 5A0BECDE6F3297DA CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:MOUSE GENOME DATABASE_MGI:2385039,
urn:biopax:RelationshipXref:NCBI GENE_224116,
urn:biopax:RelationshipXref:REFSEQ_NP_001139346,
urn:biopax:RelationshipXref:REFSEQ_NP_666183,
urn:biopax:UnificationXref:UNIPROT_Q76I84,
urn:biopax:UnificationXref:UNIPROT_Q8BUE7,
urn:biopax:UnificationXref:UNIPROT_Q8R0X0
|
| biopax3:displayName |
MUC20_MOUSE
|
| biopax3:name |
MUC-20,
Muc20
|
| biopax3:organism | |
| biopax3:sequence |
MGSVWGLAVPLLVFCWKVGVSVSSPGLDISRSVPLVTTNNMEVSTFTQRDRPSSERAFQTTNLIQYVPLDTQTLSTESASNALSATSISSEVNSRDTQTTSFVTKTRKTHTTTPAASSLEAQTTSPNLSTLNIQITSPIASSLDAQTIFPVSLSLSTQTTSPAPSFLDTQTTSPEPSSLTTSPAPSSLITSPTPSSLTTSPAPSFLDTQTTSPAPSSLTTSPAPSSLDTQTISPIELTLKTQTISTVTETRTVSIRIPSDLTVMHTIPTETLAPSNSPRTGMSTVQTGTVWDSIEAVFDTLCTDDSSEEARKITVDLLTLAHTSTEVEYLSSESSSSSDSSAGVLSSSRVLGPDSATPAKGLVAFNITHIKLSNCITEIETTITISGAPGASLSPTEATAALFTSEILTLPPPTEAKPIFPETTSLSGILSTAGTPALATTLEGTVSTSAITESETAVAQTLTSVGTSVTVRRNPLENTSTLSIETQSHTEVLGTITVPMVAGSTMGEAASFVSFTALDSSSLSVVVTTESSATSETLTTGNTTNSSFLTESHPPFSIYSTTASTSKNPNITLTKTTASPKPPTHPTTSASTAWIRKTTKHDPGEDGGFLLVRLTVASPKDLTEHNAREKLMNQLRRELHARMPLVHMSFLSIRRG
|
| biopax3:standardName |
Mucin-20
|