| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor- independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. Polyubiquitinates MYD88 (By similarity). Negatively regulates MYD88-dependent production of proinflammatory cytokines but can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, FLRF is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with USP8, ERBB3, PARK2 and BIRC6 (By similarity). Interacts with CSF2RB, EPOR, IL3RA, MYD88 and TBK1. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BH75-1; Sequence=Displayed; Name=2; IsoId=Q8BH75-2; Sequence=VSP_017316; PTM: Autoubiquitinated (By similarity). Autoubiquitination leads to proteasomal degradation (By similarity). Deubiquitinated by USP8 to get stabilized which induces apoptosis (By similarity). SIMILARITY: Contains 1 RING-type zinc finger. SIMILARITY: Contains 1 SIAH-type zinc finger. GENE SYNONYMS:Rnf41 Flrf Nrdp1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 317 AA; 35891 MW; 43FE844C06392802 CRC64;
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| biopax3:xref |
urn:biopax:RelationshipXref:MOUSE GENOME DATABASE_MGI:1914838,
urn:biopax:RelationshipXref:NCBI GENE_67588,
urn:biopax:RelationshipXref:REFSEQ_NP_001157709,
urn:biopax:RelationshipXref:REFSEQ_NP_080535,
urn:biopax:UnificationXref:UNIPROT_Q8BGJ2,
urn:biopax:UnificationXref:UNIPROT_Q8BH75,
urn:biopax:UnificationXref:UNIPROT_Q8BMC9,
urn:biopax:UnificationXref:UNIPROT_Q8VEA2,
urn:biopax:UnificationXref:UNIPROT_Q9CRK6,
urn:biopax:UnificationXref:UNIPROT_Q9D568
|
| biopax3:displayName |
RNF41_MOUSE
|
| biopax3:name |
6.3.2.-,
RING finger protein 41,
Rnf41
|
| biopax3:organism | |
| biopax3:sequence |
MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQSRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI
|
| biopax3:standardName |
E3 ubiquitin-protein ligase NRDP1
|