| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.76 mM for TEA; KM=0.11 mM for MPP; KM=0.12 mM for cimetidine; KM=1.98 mM for metformin; KM=4.2 mM for guanidine; KM=1.58 mM for procainamide; KM=0.06 mM for topotecan; KM=0.85 mM for estrone sulfate; KM=4.32 mM for acyclovir; KM=4.28 mM for ganciclovir; Vmax=0.88 nmol/min/mg enzyme toward TEA; Vmax=0.575 nmol/min/mg enzyme toward MPP; Vmax=0.115 nmol/min/mg enzyme toward cimetidine; Vmax=0.845 nmol/min/mg enzyme toward metformin; Vmax=0.58 nmol/min/mg enzyme toward guanidine; Vmax=3.385 nmol/min/mg enzyme toward procainamide; Vmax=0.13 nmol/min/mg enzyme toward topotecan; Vmax=0.425 nmol/min/mg enzyme toward estrone sulfate; Vmax=0.945 nmol/min/mg enzyme toward acyclovir; Vmax=0.805 nmol/min/mg enzyme toward ganciclovir; pH dependence: Optimum pH is 9.0. Active from pH 6 to 9; SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (Potential). Note=Localized at the brush border membranes of the proximal tubules. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q86VL8-1; Sequence=Displayed; Name=2; IsoId=Q86VL8-2; Sequence=VSP_029656, VSP_029658, VSP_029663, VSP_029664; Note=No experimental confirmation available; Name=3; Synonyms=MATE2-K; IsoId=Q86VL8-3; Sequence=VSP_029658; Note=No experimental confirmation available; Name=4; IsoId=Q86VL8-4; Sequence=VSP_029658, VSP_029662; Note=No experimental confirmation available; Name=5; IsoId=Q86VL8-5; Sequence=VSP_029658, VSP_029660, VSP_029661; Note=No experimental confirmation available; Name=6; Synonyms=MATE2-B; IsoId=Q86VL8-6; Sequence=VSP_029657, VSP_029659; Note=Inactive. Note=No experimental confirmation available; TISSUE SPECIFICITY: Isoform 3 is predominantly expressed in kidney. Isoform 6 is expressed in brain. SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. GENE SYNONYMS:SLC47A2 MATE2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 602 AA; 65085 MW; 88EB90286AE701D1 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:26439,
urn:biopax:RelationshipXref:NCBI GENE_146802,
urn:biopax:RelationshipXref:REFSEQ_NP_001093116,
urn:biopax:RelationshipXref:REFSEQ_NP_001243592,
urn:biopax:RelationshipXref:REFSEQ_NP_690872,
urn:biopax:UnificationXref:UNIPROT_A0JBX9,
urn:biopax:UnificationXref:UNIPROT_A0P8Z7,
urn:biopax:UnificationXref:UNIPROT_Q63HJ9,
urn:biopax:UnificationXref:UNIPROT_Q86VL8,
urn:biopax:UnificationXref:UNIPROT_Q8IV44,
urn:biopax:UnificationXref:UNIPROT_Q96NA1
|
| biopax3:displayName |
S47A2_HUMAN
|
| biopax3:name |
Kidney-specific H(+)/organic cation antiporter,
MATE-2,
SLC47A2,
Solute carrier family 47 member 2,
hMATE-2
|
| biopax3:organism | |
| biopax3:sequence |
MDSLQDTVALDHGGCCPALSRLVPRGFGTEMWTLFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCGVSVGVGLSSACDTLMSQSFGSPNKKHVGVILQRGALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQGWLKGQEEESPFQTPGLSILHPSHSHLSRASFHLFQKITWPQVLSGVVGNCVNGVANYALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSLAVPSMLMICVEWWAYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMIPLGLSIGVCVRVGMALGAADTVQAKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQAFGAAVNAITYYIIGLPLGILLTFVVRMRIMGLWLGMLACVFLATAAFVAYTARLDWKLAAEEAKKHSGRQQQQRAESTATRPGPEKAVLSSVATGSSPGITLTTYSRSECHVDFFRTPEEAHALSAPTSRLSVKQLVIRRGAALGAASATLMVGLTVRILATRH
|
| biopax3:standardName |
Multidrug and toxin extrusion protein 2
|