| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions. SUBUNIT: Interacts with the C-terminal region of GUCY2C. Interacts with the C-terminal region of SLC34A1. Interacts with the C- terminal region SLC9A3 and the interactions decrease in response to elevated calcium ion levels. SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Cytoplasm. Note=Preferentially accumulates at the apical surface and ileal brush border of intestinal epithelial cells. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q86UT5-1; Sequence=Displayed; Name=2; IsoId=Q86UT5-2; Sequence=VSP_051786, VSP_051787; Name=3; IsoId=Q86UT5-3; Sequence=VSP_051786, VSP_051787, VSP_051788; Note=No experimental confirmation available; Name=4; IsoId=Q86UT5-4; Sequence=VSP_051790, VSP_051791; Note=No experimental confirmation available; Name=5; IsoId=Q86UT5-5; Sequence=VSP_051786, VSP_051787, VSP_051789; Note=No experimental confirmation available; TISSUE SPECIFICITY: Expressed in kidney and the gastrointestinal tract. Not detected in brain, heart, skeletal muscle or cells of hematopoietic origin. SIMILARITY: Contains 4 PDZ (DHR) domains. GENE SYNONYMS:PDZD3 IKEPP NHERF4 PDZK2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 571 AA; 61032 MW; B56CDC91348EE592 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:19891,
urn:biopax:RelationshipXref:NCBI GENE_79849,
urn:biopax:RelationshipXref:REFSEQ_NP_001161940,
urn:biopax:RelationshipXref:REFSEQ_NP_079067,
urn:biopax:UnificationXref:UNIPROT_Q86UT5,
urn:biopax:UnificationXref:UNIPROT_Q8N6R4,
urn:biopax:UnificationXref:UNIPROT_Q8NAW7,
urn:biopax:UnificationXref:UNIPROT_Q8NEX7,
urn:biopax:UnificationXref:UNIPROT_Q9H5Z3
|
| biopax3:displayName |
NHRF4_HUMAN
|
| biopax3:name |
Intestinal and kidney-enriched PDZ protein,
NHERF-4,
Na/Pi cotransporter C-terminal-associated protein 2,
NaPi-Cap2,
Natrium-phosphate cotransporter IIa C-terminal-associated protein 2,
PDZ domain-containing protein 2,
PDZ domain-containing protein 3,
PDZD3,
Sodium-hydrogen exchanger regulatory factor 4
|
| biopax3:organism | |
| biopax3:sequence |
MVTPSPPGNHSLSLEAPRLHTASDLLGNHSLGLPLITALVGSRDRRGRVFSPVPVPLPTNPTTQHPTRQKLPSTLSGHRVCQAHGEPVLGLCPLLPLFCCPPHPPDPWSLERPRFCLLSKEEGKSFGFHLQQELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEHEDYAVVVRRIRASSPRVLLTVLARHAHDVARAQLGEDAHLCPTLGPGVRPRLCHIVKDEGGFGFSVTHGNQGPFWLVLSTGGAAERAGVPPGARLLEVNGVSVEKFTHNQLTRKLWQSGQQVTLLVAGPEVEEQCRQLGLPLAAPLAEGWALPTKPRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVAVAGESVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAPASPRGSSSASLVETEDPSLEDTSVPSVPLGSRQCFLYPGPGGSYGFRLSCVASGPRLFISQVTPGGSAARAGLQVGDVILEVNGYPVGGQNDLERLQQLPEAEPPLCLKLAARSLRGLEAWIPPGAAEDWALASDLL
|
| biopax3:standardName |
Na(+)/H(+) exchange regulatory cofactor NHE-RF4
|