| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV). SUBUNIT: Interacts (via region A) with DDX6/RCK. Interacts (via region H and region C) with LSM1 and LSM4. Interacts (via region N) with DCP1A, DCP2, EDC3, EDC4 and XRN1. Interacts with the CCR4- NOT complex. Interacts with the Lsm-containing SMN-Sm protein complex. SUBCELLULAR LOCATION: Cytoplasm, P-body. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q86TB9-1; Sequence=Displayed; Name=2; IsoId=Q86TB9-2; Sequence=VSP_031778; Name=3; IsoId=Q86TB9-3; Sequence=VSP_031777; Name=4; IsoId=Q86TB9-4; Sequence=VSP_040576, VSP_040577; Note=No experimental confirmation available; TISSUE SPECIFICITY: Ubiquitous. DOMAIN: The region A, also named N-term, mediates the interaction with DDX6/RCK and is required for cytoplasmic mRNA processing body assembly. DOMAIN: The region C, also named Pat-C, is required for RNA- binding and mediates the binding with the Lsm-containing SMN-Sm protein complex and the decapping machinery. It folds into an alpha-alpha superhelix, exposing conserved and basic residues on one side of the domain. SIMILARITY: Belongs to the PAT1 family. SEQUENCE CAUTION: Sequence=CAD89916.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; GENE SYNONYMS:PATL1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 770 AA; 86850 MW; 65F7038C4AAC356B CRC64;
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| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:26721,
urn:biopax:RelationshipXref:NCBI GENE_219988,
urn:biopax:RelationshipXref:REFSEQ_NP_689929,
urn:biopax:UnificationXref:UNIPROT_B3KXT9,
urn:biopax:UnificationXref:UNIPROT_Q2TA86,
urn:biopax:UnificationXref:UNIPROT_Q6P166,
urn:biopax:UnificationXref:UNIPROT_Q86TB9,
urn:biopax:UnificationXref:UNIPROT_Q8N9M6,
urn:biopax:UnificationXref:UNIPROT_Q8NI63
|
| biopax3:displayName |
PATL1_HUMAN
|
| biopax3:name |
PAT1-like protein 1,
PATL1,
Pat1b,
Protein PAT1 homolog b,
hPat1b
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MFRYESLEDCPLDEDEDAFQGLGEEDEEIDQFNDDTFGSGAVDDDWQEAHERLAELEEKLPVAVNEQTGNGERDEMDLLGDHEENLAERLSKMVIENELEDPAIMRAVQTRPVLQPQPGSLNSSIWDGSEVLRRIRGPLLAQEMPTVSVLEYALPQRPPQGPEDDRDLSERALPRRSTSPIIGSPPVRAVPIGTPPKQMAVPSFTQQILCPKPVHVRPPMPPRYPAPYGERMSPNQLCSVPNSSLLGHPFPPSVPPVLSPLQRAQLLGGAQLQPGRMSPSQFARVPGFVGSPLAAMNPKLLQGRVGQMLPPAPGFRAFFSAPPSATPPPQQHPPGPGPHLQNLRSQAPMFRPDTTHLHPQHRRLLHQRQQQNRSQHRNLNGAGDRGSHRSSHQDHLRKDPYANLMLQREKDWVSKIQMMQLQSTDPYLDDFYYQNYFEKLEKLSAAEEIQGDGPKKERTKLITPQVAKLEHAYKPVQFEGSLGKLTVSSVNNPRKMIDAVVTSRSEDDETKEKQVRDKRRKTLVIIEKTYSLLLDVEDYERRYLLSLEEERPALMDDRKHKICSMYDNLRGKLPGQERPSDDHFVQIMCIRKGKRMVARILPFLSTEQAADILMTTARNLPFLIKKDAQDEVLPCLLSPFSLLLYHLPSVSITSLLRQLMNLPQSAATPALSNPHLTAVLQNKFGLSLLLILLSRGEDLQSSDPATESTQNNQWTEVMFMATRELLRIPQAALAKPISIPTNLVSLFSRYVDRQKLNLLETKLQLVQGIR
|
| biopax3:standardName |
Protein PAT1 homolog 1
|