| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity). SUBUNIT: On tyrosine phosphorylation, interacts with CSK and INPP5D/SHIP1 via their SH2 domains. Both Tyr-381 and Tyr-398 are required for interaction with INPP5D. Only Tyr-381 is required for interaction with CSK. Binds ABL1 through the PTB domain and in a kinase-dependent manner. Does not interact with RasGAP (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q7L591-1; Sequence=Displayed; Note=No experimental confirmation available; Name=2; IsoId=Q7L591-2; Sequence=VSP_013713, VSP_013715, VSP_013716; Note=No experimental confirmation available; Name=3; IsoId=Q7L591-3; Sequence=VSP_013712, VSP_013715, VSP_013716; Note=No experimental confirmation available; Name=4; IsoId=Q7L591-4; Sequence=VSP_013712, VSP_013714, VSP_013715, VSP_013716; Note=No experimental confirmation available; TISSUE SPECIFICITY: Expressed in spleen. DOMAIN: PTB domain mediates receptor interaction (By similarity). PTM: Constitutively tyrosine-phosphorylated (By similarity). PTM: On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL1 kinase (By similarity). SIMILARITY: Belongs to the DOK family. Type A subfamily. SIMILARITY: Contains 1 IRS-type PTB domain. SIMILARITY: Contains 1 PH domain. GENE SYNONYMS:DOK3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 496 AA; 53288 MW; 7E186B998F9F1E24 CRC64;
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| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:24583,
urn:biopax:RelationshipXref:NCBI GENE_79930,
urn:biopax:RelationshipXref:REFSEQ_NP_001138347,
urn:biopax:RelationshipXref:REFSEQ_NP_001138348,
urn:biopax:RelationshipXref:REFSEQ_NP_079148,
urn:biopax:UnificationXref:UNIPROT_Q7L591,
urn:biopax:UnificationXref:UNIPROT_Q8N864,
urn:biopax:UnificationXref:UNIPROT_Q9BQB3,
urn:biopax:UnificationXref:UNIPROT_Q9H666
|
| biopax3:displayName |
DOK3_HUMAN
|
| biopax3:name |
DOK3,
Downstream of tyrosine kinase 3
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MTRGARLRSDARAQLNQLSLDGGTGSGQKGKCEEFPSSLSSVSPGLEAAALLLAVTMDPLETPIKDGILYQQHVKFGKKCWRKVWALLYAGGPSGVARLESWEVRDGGLGAAGDRSAGPGRRGERRVIRLADCVSVLPADGESCPRDTGAFLLTTTERSHLLAAQHRQAWMGPICQLAFPGTGEASSGSTDAQSPKRGLVPMEENSIYSSWQEVGEFPVVVQRTEAATRCQLKGPALLVLGPDAIQLREAKGTQALYSWPYHFLRKFGSDKGVFSFEAGRRCHSGEGLFAFSTPCAPDLCRAVAGAIARQRERLPELTRPQPCPLPRATSLPSLDTPGELREMPPGPEPPTSRKMHLAEPGPQSLPLLLGPEPNDLASGLYASVCKRASGPPGNEHLYENLCVLEASPTLHGGEPEPHEGPGSRSPTTSPIYHNGQDLSWPGPANDSTLEAQYRRLLELDQVEGTGRPDPQAGFKAKLVTLLSRERRKGPAPCDRP
|
| biopax3:standardName |
Docking protein 3
|